Chen Cong, Ye Qianwei, Wang Linbo, Zhou Jichun, Xiang Aizhai, Lin Xia, Guo Jufeng, Hu Shufang, Rui Tao, Liu Jian
Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Cell Death Discov. 2023 Feb 23;9(1):75. doi: 10.1038/s41420-023-01370-9.
Pyroptosis is a lytic and inflammatory type of programmed cell death that is mediated by Gasdermin proteins (GSDMs). Attractively, recent evidence indicates that pyroptosis involves in the development of tumors and can serve as a new strategy for cancer treatment. Here, we present a basic knowledge of pyroptosis, and an overview of the expression patterns and roles of GSDMs in breast cancer. In addition, we further summarize the available evidence of pyroptosis in breast cancer progression and give insight into the clinical potential of applying pyroptosis in anticancer strategies for breast cancer. This review will deepen our understanding of the relationship between pyroptosis and breast cancer, and provide a novel potential therapeutic avenue for breast cancer.
细胞焦亡是一种由Gasdermin蛋白（GSDMs）介导的溶解性和炎症性程序性细胞死亡。引人注目的是，最近的证据表明细胞焦亡参与肿瘤的发生发展，并可作为癌症治疗的新策略。在此，我们介绍细胞焦亡的基础知识，概述GSDMs在乳腺癌中的表达模式和作用。此外，我们进一步总结了细胞焦亡在乳腺癌进展中的现有证据，并深入探讨将细胞焦亡应用于乳腺癌抗癌策略的临床潜力。本综述将加深我们对细胞焦亡与乳腺癌之间关系的理解，并为乳腺癌提供一种新的潜在治疗途径。
