Chen Cong, Xiang Aizhai, Lin Xia, Guo Jufeng, Liu Jian, Hu Shufang, Rui Tao, Ye Qianwei
Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Cell Death Discov. 2024 Oct 29;10(1):457. doi: 10.1038/s41420-024-02226-6.
Mitophagy, a form of selective autophagy that removes damaged or dysfunctional mitochondria, plays a crucial role in maintaining mitochondrial and cellular homeostasis. Recent findings suggest that defective mitophagy is closely associated with various diseases, including breast cancer. Moreover, a better understanding of the multifaceted roles of mitophagy in breast cancer progression is crucial for the treatment of this disease. Here, we will summarize the molecular mechanisms of mitophagy process. In addition, we highlight the expression patterns and roles of mitophagy-related signaling molecules in breast cancer progression and the potential implications of mitophagy for the development of breast cancer, aiming to provide better therapeutic strategies for breast cancer treatment.
线粒体自噬是一种选择性自噬形式，可清除受损或功能失调的线粒体，在维持线粒体和细胞内稳态中发挥关键作用。最近的研究结果表明，线粒体自噬缺陷与包括乳腺癌在内的多种疾病密切相关。此外，深入了解线粒体自噬在乳腺癌进展中的多方面作用对于该疾病的治疗至关重要。在此，我们将总结线粒体自噬过程的分子机制。此外，我们强调线粒体自噬相关信号分子在乳腺癌进展中的表达模式和作用以及线粒体自噬对乳腺癌发展的潜在影响，旨在为乳腺癌治疗提供更好的治疗策略。
