Department of Traditional Chinese Medicine, Shandong College of Traditional Chinese Medicine, Yantai, China.
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China.
Nat Prod Res. 2024 Jul;38(14):2480-2485. doi: 10.1080/14786419.2023.2183500. Epub 2023 Feb 23.
Alterbutenolide (), a new butenolide derivative with a long-chain aliphatic acid substitution, together with seven known phenolic compounds i.e. alternariol (), asperigillol B (), -hydroxyphenylacetic acid (), -hydroxyphenylethyl alcohol (), methyl -hydroxyphenyl acetate (), 2-(4-hydroxyphenyl)ethyl acetate (), and 5,6-dihydro-4-methyl-2-pyran-2-one (), was isolated from the cultures of a sponge-derived fungus I-YLW6-1. The structure of was established on the basis of HR-MS, 1D and 2D NMR, as well as by comparison of the optical rotation data with the literature reported. Compounds and showed significant to moderate inhibitory activities against three harmful microalgae with IC values from 3.0 to 36.2 μg/mL, whereas compound only displayed moderate inhibition against with IC value of 34.6 μg/mL. Meanwhile, compounds and showed weak toxicity against brine shrimp larvae with LC values >100 μg/mL.
阿替布醇内酯 ()，一种具有长链脂肪酸取代基的新型丁烯内酯衍生物，与七种已知的酚类化合物即交替醇 ()、asperigillol B ()、-羟基苯乙酸 ()、-羟基苯乙醇 ()、甲基 -羟基苯乙酸酯 ()、2-(4-羟基苯基)乙基乙酸酯 ()和 5,6-二氢-4-甲基-2-吡喃-2-酮 ()一起，从海绵衍生真菌 I-YLW6-1 的培养物中分离得到。根据高分辨质谱、1D 和 2D NMR 以及与文献报道的旋光数据比较，确定了的结构。化合物 和 对三种有害微藻表现出显著到中等的抑制活性，IC 值范围为 3.0 至 36.2μg/mL，而化合物 仅对 表现出中等抑制活性，IC 值为 34.6μg/mL。同时，化合物 和 对卤虫幼虫表现出较弱的毒性，LC 值 >100μg/mL。
