从深海真菌 SCSIO FZQ028 中分离得到的一种新的丁烯内酯衍生物。

A new butenolide derivative from the deep-sea fungus SCSIO FZQ028.

机构信息

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of sciences, Guangzhou, P.R. China.

University of Chinese Academy of Sciences, Beijing, P.R. China.

出版信息

Nat Prod Res. 2020 Jul;34(14):1984-1991. doi: 10.1080/14786419.2019.1569658. Epub 2019 Feb 5.

DOI:10.1080/14786419.2019.1569658

PMID:30721083

Abstract

A new butenolide derivative (±)-asperteretal F () and related congener () recently reported containing an unusual 2-benzyl-3-phenyl substituted lactone core, together with five known compounds (-) were isolated and characterized from the fungus . SCSIO FZQ028 derived from a deep-sea sediment of South China Sea. Their chemical structures were established on the basis of 1D- and 2D-NMR spectroscopic data, and HR-ESI-MS analysis. Additionally, all the compounds were evaluated for the antioxidative activities against DPPH, cytotoxic activities against two tumor cell lines (SF-268 and HepG-2), and antimicrobial activities. Compounds -, and showed significant activities against DPPH with IC ranging from 5.89 to 10.07 μg/mL. Compounds and showed moderate antimicrobial activities against all four tested bacteria.[Figure: see text].

摘要

从南海深海沉积物中分离得到的真菌 SCSIO FZQ028 中，分离得到了一个新的丁烯内酯衍生物（±）-asperteretal F（()）和相关的同系物（()），它们都含有一个不寻常的 2-苄基-3-苯基取代的内酯核心，此外还有五个已知化合物（-）。基于 1D 和 2D-NMR 光谱数据和 HR-ESI-MS 分析确定了它们的化学结构。此外，还评估了所有化合物对 DPPH 的抗氧化活性、对两种肿瘤细胞系（SF-268 和 HepG-2）的细胞毒性活性以及对微生物的抗菌活性。化合物-、和-对 DPPH 具有显著的活性，IC 范围为 5.89 至 10.07μg/mL。化合物和-对所有四种测试的细菌均具有中等的抗菌活性。[图：见正文]。