Takada Yukihisa, Sumioka Takayoshi, Tamura Tadahiko, Saika Shizuya
Department of Ophthalmology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, Japan.
Case Rep Ophthalmol Med. 2023 Feb 14;2023:9529229. doi: 10.1155/2023/9529229. eCollection 2023.
We herein report a case of glaucoma with an intraocular pressure (IOP) decrease following total gastrectomy (TG) and anticancer treatment for gastric cancer. A 62-year-old male underwent trabeculectomy of the left and right eyes in August 2011 and July 2012, respectively. During the follow-up, IOP of the right eye was 9-12 mmHg (with bimatoprost, dorzolamide, and timolol maleate), and that of the left eye ranged between 14 and 26 mmHg (with bimatoprost, dorzolamide, timolol maleate, and brimonidine tartrate). In December 2014, TG was performed due to gastric cancer. After surgery, the patient received S-1+CDDP, weekly PAC, and CPT-11 therapies. The patient died on March X, 2017. Before TG, the body mass index (BMI) was 29.5 but decreased to 24.8 before the start of the two courses of weekly PAC therapy. IOP of the right eye was 6 mmHg (with bimatoprost), and that of the left eye was 10 mmHg (with bimatoprost, dorzolamide, and brimonidine tartrate), showing decreases. After the initiation of weekly PAC therapy, BMI was approximately 19. IOP of the right eye ranged between 6 and 10 mmHg until the final ophthalmological examination (January 11, 2017), while that of the left eye ranged between 8 and 15 mmHg. In this patient with glaucoma, IOP was not controlled by eye drop treatment, and TG for gastric cancer and postoperative treatment with anticancer drugs resulted in weight loss and a decrease in IOP.
我们在此报告一例青光眼患者，其在全胃切除（TG）及胃癌抗癌治疗后眼压（IOP）降低。一名62岁男性分别于2011年8月和2012年7月接受了左右眼小梁切除术。随访期间，右眼眼压为9 - 12 mmHg（使用比马前列素、多佐胺和马来酸噻吗洛尔），左眼眼压在14至26 mmHg之间（使用比马前列素、多佐胺、马来酸噻吗洛尔和酒石酸溴莫尼定）。2014年12月，因胃癌进行了全胃切除术。术后，患者接受了S - 1 +顺铂、每周一次的紫杉醇联合顺铂（PAC）和伊立替康（CPT - 11）治疗。患者于2017年3月X日死亡。全胃切除术前，体重指数（BMI）为29.5，但在开始两疗程每周一次的PAC治疗前降至24.8。右眼眼压为6 mmHg（使用比马前列素），左眼眼压为10 mmHg（使用比马前列素、多佐胺和酒石酸溴莫尼定），均出现降低。开始每周一次的PAC治疗后，BMI约为19。直至最后一次眼科检查（2017年1月11日），右眼眼压在6至10 mmHg之间，而左眼眼压在8至15 mmHg之间。在该青光眼患者中，滴眼液治疗无法控制眼压，而胃癌的全胃切除术及术后抗癌药物治疗导致体重减轻和眼压降低。
