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泛素-蛋白酶体途径注释可揭示基于RNA干扰的害虫治理潜在靶点。

Ubiquitin-proteasome pathway annotation in can reveal potential targets for RNAi-based pest management.

作者信息

Tank Will, Shippy Teresa, Thate Amanda, Massimino Crissy, Hosmani Prashant S, Flores-Gonzalez Mirella, Mueller Lukas A, Hunter Wayne B, Brown Susan J, D'Elia Tom, Saha Surya

机构信息

Division of Biology, Kansas State University, Manhattan, KS 66506, USA.

Indian River State College, Fort Pierce, FL 34981, USA.

出版信息

GigaByte. 2022 Mar 2;2022:gigabyte43. doi: 10.46471/gigabyte.43. eCollection 2022.

DOI:10.46471/gigabyte.43
PMID:36824528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9933519/
Abstract

Ubiquitination is an ATP-dependent process that targets proteins for degradation by the proteasome. Here, we annotated 15 genes from the ubiquitin-proteasome pathway in the Asian citrus psyllid, . This psyllid vector has come to prominence in the last decade owing to its role in the transmission of the devastating bacterial pathogen, Liberibacter asiaticus (Las). Infection of citrus crops by this pathogen causes Huanglongbing (HLB), or citrus greening disease, and results in the eventual death of citrus trees. The identification and correct annotation of these genes in will be useful for functional genomic studies to aid the development of RNAi-based management strategies aimed at reducing the spread of HLB. Investigating the effects of Las infection on the expression of ubiquitin-proteasome pathway genes may provide new information about the role these genes play in the acquisition and transmission of Las by .

摘要

泛素化是一种依赖ATP的过程,该过程将蛋白质靶向蛋白酶体进行降解。在此,我们注释了亚洲柑橘木虱中泛素-蛋白酶体途径的15个基因。在过去十年中,这种木虱传播媒介因其在传播毁灭性细菌病原体——亚洲韧皮杆菌(Las)中的作用而备受关注。这种病原体感染柑橘作物会导致黄龙病(HLB),即柑橘绿变病,并最终导致柑橘树死亡。在亚洲柑橘木虱中对这些基因进行鉴定和正确注释,将有助于功能基因组学研究,以辅助开发基于RNA干扰的管理策略,旨在减少HLB的传播。研究Las感染对泛素-蛋白酶体途径基因表达的影响,可能会提供有关这些基因在亚洲柑橘木虱获取和传播Las过程中所起作用的新信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1cc/9933519/e01b897c3b81/gigabyte-2022-43-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1cc/9933519/db443727cf64/gigabyte-2022-43-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1cc/9933519/0418f9e94037/gigabyte-2022-43-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1cc/9933519/2bfb48e94310/gigabyte-2022-43-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1cc/9933519/e01b897c3b81/gigabyte-2022-43-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1cc/9933519/db443727cf64/gigabyte-2022-43-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1cc/9933519/0418f9e94037/gigabyte-2022-43-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1cc/9933519/2bfb48e94310/gigabyte-2022-43-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1cc/9933519/e01b897c3b81/gigabyte-2022-43-g004.jpg

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