Rad Parastou, Tadayon Mitra, Abbaspour Mohammadreza, Latifi Seyed Mahmood, Rashidi Iran, Delaviz Hamdollah
Department of Midwifery, Yasuj University of Medical Sciences, Yasuj, Iran.
Department of Midwifery, Faculty of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Iran J Nurs Midwifery Res. 2015 Mar-Apr;20(2):211-5.
Most of the women suffer from vaginal atrophy and dryness, and therefore, efficient and safe treatment is needed to improve vaginal lubrication. Vitamin D has several important functions which may be effective in proliferation and repair of the epithelial tissue. This study aimed to evaluate the effect of vitamin D vaginal suppositories on maturation index, pH, and dryness in postmenopausal women.
Women were enrolled in this double-blind clinical trial, in whom menopause occurred at least one year ago. Those women who had an abnormal Papanicolaou smear, had undergone hormonal treatment, or have had vaginal infection in the previous year were excluded. Forty-four women who found eligible were randomized into two equal groups, the treatment and control groups, which received vitamin D and placebo vaginal suppository daily for 8 weeks, respectively. Vaginal pH and maturation value were measured at the beginning and end of the study. Pain, dryness, and paleness were assessed before treatment and at the end of the 2, 4, and 8 weeks of treatment.
In the treatment group, the number (Mean ± SD) of superficial cells increased (69.76 ± 12.4) and vaginal pH decreased (1.42 ± 0.67) significantly compared to the control group after 56 days. The mean pain significantly reduced after 8 weeks in the treatment group (1.23 ± 0.53) compared to the control group 1.95 ± 0.74 (P < 0.001). The mean of dryness and paleness reduced significantly in the treatment group versus control at 56 days.
Vitamin D is effective in improving the maturation index and decreased the pH and dryness of the vaginal atrophy due to menopause.
大多数女性患有阴道萎缩和干燥，因此，需要有效且安全的治疗方法来改善阴道润滑。维生素D具有多种重要功能，可能对上皮组织的增殖和修复有效。本研究旨在评估维生素D阴道栓剂对绝经后女性成熟指数、pH值和干燥程度的影响。
女性参与了这项双盲临床试验，她们至少在一年前绝经。排除那些巴氏涂片异常、接受过激素治疗或在前一年有过阴道感染的女性。44名符合条件的女性被随机分为两组，治疗组和对照组，分别每天接受维生素D和安慰剂阴道栓剂治疗8周。在研究开始和结束时测量阴道pH值和成熟值。在治疗前以及治疗第2、4和8周结束时评估疼痛、干燥和苍白程度。
治疗组中，56天后与对照组相比，表层细胞数量（平均值±标准差）显著增加（69.76±12.4），阴道pH值降低（1.42±0.67）。与对照组（1.95±0.74）相比，治疗组8周后平均疼痛程度显著降低（1.23±0.53）（P<0.001）。治疗组在56天时干燥和苍白程度的平均值与对照组相比显著降低。
维生素D在改善成熟指数以及降低绝经引起的阴道萎缩的pH值和干燥程度方面有效。
