Department of Pathology & Lab Medicine, AIIMS Jodhpur, Jodhpur, India.
Department of Pathology, All India Institute of Medical Science, Mangalagiri, India.
Cytopathology. 2023 Jul;34(4):377-380. doi: 10.1111/cyt.13224. Epub 2023 Mar 15.
Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland carcinoma that resembles the secretory carcinoma of the breast and is characterised by t(12;15) (q13;q25) translocation, which results in an ETV6-NTRK3 gene fusion product. On cytomorphology, it is characterised by papillary fragments, clusters, and singly dispersed tumour cells. These tumour cells are large and have abundant vacuolated cytoplasm. Acinic cell carcinoma of the salivary gland is the most common differential diagnosis of MASC. Other differentials include mucoepidermoid carcinoma, salivary duct carcinoma, pleomorphic adenoma, and oncocytic salivary gland neoplasms. Immunohistochemistry and morphology are critical in establishing the correct diagnosis. We present a case of a 46-year-old male patient diagnosed as MASC of the parotid gland on fine needle aspiration cytology and cell block.
乳腺型分泌性癌（MASC）是一种新近描述的唾液腺癌，其类似于乳腺的分泌性癌，其特征在于 t（12；15）（q13；q25）易位，导致 ETV6-NTRK3 基因融合产物。在细胞形态学上，它的特征是乳头状碎片、簇状和单个分散的肿瘤细胞。这些肿瘤细胞较大，有空泡状细胞质。唾液腺的腺样囊性癌是 MASC 的最常见鉴别诊断。其他鉴别诊断包括黏液表皮样癌、唾液导管癌、多形性腺瘤和嗜酸细胞性唾液腺肿瘤。免疫组织化学和形态学在确立正确诊断中至关重要。我们提出了一例 46 岁男性患者的病例，该患者在细针穿刺细胞学和细胞块中被诊断为腮腺的 MASC。
