Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Cancer Cytopathol. 2013 May;121(5):234-41. doi: 10.1002/cncy.21249. Epub 2012 Dec 5.
Mammary analogue secretory carcinoma (MASC) of the salivary glands is a newly described tumor entity associated with the t(12;15)(p13;q25) ETV6-NTRK3 translocation. Early studies have shown this tumor to be a distinct entity with histologic, biologic, and clinical differences from acinic cell carcinoma and adenocarcinoma, not otherwise specified. Because this tumor was described only recently, it remains relatively unknown outside of head and neck specialty pathology centers.
In the current study, 6 cases of fine-needle aspiration cytology from histologically and/or molecularly confirmed cases of MASC are presented.
Using cytomorphology, MASC primarily raises the differential diagnosis of an oncocytic salivary gland tumor but there are some features that can suggest the specific diagnosis of MASC. The 6 cases presented in the current study all demonstrated at least focal cytoplasmic vacuolization and papillary formations on smears. MASC can be differentiated from acinic cell carcinoma by a lack of periodic acid-Schiff diastase-positive zymogen granules and S-100 protein positivity.
The results of the current study the ability of ETV6 break-apart fluorescence in situ hybridization to detect gene rearrangement on cell block material. This is the first report of a case of MASC prospectively diagnosed on a cytology specimen.
乳腺样分泌性癌（MASC）是一种新描述的唾液腺肿瘤实体，与 t(12;15)(p13;q25)ETV6-NTRK3 易位相关。早期研究表明，该肿瘤具有独特的组织学、生物学和临床特征，与腺泡细胞癌和非特指性腺癌不同。由于这种肿瘤最近才被描述，因此除了头颈部专业病理中心外，它在其他地方相对不为人知。
本研究中，展示了 6 例经组织学和/或分子学证实的 MASC 细针抽吸细胞学病例。
通过细胞学形态学，MASC 主要引起毛细胞性唾液腺肿瘤的鉴别诊断，但有一些特征可以提示 MASC 的特定诊断。本研究中介绍的 6 例病例在涂片上均显示出至少局灶性细胞质空泡化和乳头状形成。MASC 可以通过缺乏过碘酸-希夫（PAS）阳性酶原颗粒和 S-100 蛋白阳性与腺泡细胞癌区分开来。
本研究结果表明 ETV6 断裂分离荧光原位杂交在检测细胞块材料基因重排方面的能力。这是首例前瞻性诊断为 MASC 的细胞学标本的报告。
