Department of Pathology, Baylor Scott & White Medical Center and Texas A&M Health Science Center College of Medicine, Temple, TX, USA.
Head Neck Pathol. 2022 Jun;16(2):567-572. doi: 10.1007/s12105-021-01361-1. Epub 2021 Jul 13.
Secretory carcinoma (SC) of salivary gland, previously known as mammary analogue secretory carcinoma, is a rare low-grade malignancy harboring a diagnostic ETV6-NTRK3 gene fusion. SC of salivary gland shares histopathological, immunohistochemical and genetic characteristics with SC of the breast. There are several previous cytomorphological characterizations of SC of salivary gland reported in the literature. The most commonly reported patterns are of epithelial clusters with papillary architectural features, or of single dispersed epithelial cells on a background of abundant histiocytes. Tumor cells exhibit vacuolated eosinophilic cytoplasm and round to oval nuclei with regular nuclear contours and inconspicuous or small nucleoli. The cytomorphology of SC may closely mimic that of acinic cell carcinoma or low-grade mucoepidermoid carcinoma. Moreover, when cohesive epithelial clusters do not appear on the smears, it may be very difficult to distinguish dispersed tumor cells from histiocytes. In this article, we review the literature pertaining to SC cytomorphology and we report a fine needle aspiration biopsy case of SC in salivary gland showing well-defined intracytoplasmic hyaline globules, a feature that has not been previously reported. This novel cytomorphological feature may be helpful in distinguishing the tumor cells of SC from histiocytes and from other low-grade salivary gland tumors.
涎腺分泌性癌（SC），以前称为乳腺类似分泌性癌，是一种罕见的低度恶性肿瘤，具有诊断意义的 ETV6-NTRK3 基因融合。涎腺 SC 在组织病理学、免疫组织化学和遗传学特征上与乳腺 SC 相似。有几项关于涎腺 SC 的细胞形态学特征已在文献中报道。最常报道的模式是具有乳头状结构特征的上皮簇，或在丰富的组织细胞背景下存在单个分散的上皮细胞。肿瘤细胞表现出空泡状嗜酸性细胞质和圆形至椭圆形核，核轮廓规则，核仁不明显或小。SC 的细胞形态学可能与浆液性细胞癌或低度黏液表皮样癌非常相似。此外，当涂片上没有出现聚集的上皮簇时，很难将分散的肿瘤细胞与组织细胞区分开来。本文回顾了有关 SC 细胞形态学的文献，并报告了一例显示明确的细胞内透明小体的涎腺 SC 的细针抽吸活检病例，这一特征以前尚未报道过。这种新的细胞形态学特征可能有助于将 SC 的肿瘤细胞与组织细胞以及其他低度涎腺肿瘤区分开来。
