Department of Hepatobiliary Surgery, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Zhuhui, Hengyang, Hunan 421002, P.R. China.
Radiotherapy Center, Department of Oncology, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Zhuhui, Hengyang, Hunan 421002, P.R. China.
Oncol Rep. 2023 Apr;49(4). doi: 10.3892/or.2023.8506. Epub 2023 Feb 24.
As a leading cause of mortalities worldwide, cancer results from accumulation of both genetic and epigenetic alterations. Disruption of epigenetic regulation in cancer, particularly aberrant ubiquitination, has drawn increasing interest in recent years. The present study aimed to review the roles of ubiquitin‑conjugating enzyme E2 T (UBE2T) and its associated pathways in the pathogenesis of pan‑cancer, and the development of small‑molecule modulators to regulate ubiquitination for treatment strategies. The current study comprehensively investigated the expression landscape and functional significance of UBE2T, as well as its correlation with cancer cell sensitivity to chemotherapy/radiotherapy. Multiple levels of evidence suggested that aberrant UBE2T played important roles in pan‑cancer. Information was collected from 16 clinical trials on ubiquitin enzymes, and it was found that these molecules had an important role in the ubiquitin‑proteasome system. Further studies are necessary to explore their feasibility and effectiveness as diagnostic and prognostic biomarkers, or as up/down‑stream and therapeutic targets for cancer treatment.
作为全球死亡率的主要原因之一，癌症是由遗传和表观遗传改变的积累引起的。近年来，癌症中表观遗传调控的破坏，特别是异常的泛素化，引起了越来越多的关注。本研究旨在综述泛癌中泛素连接酶 E2 T（UBE2T）及其相关途径的作用，以及开发小分子调节剂来调节泛素化以制定治疗策略。本研究全面研究了 UBE2T 的表达谱和功能意义，以及其与癌细胞对化疗/放疗敏感性的相关性。多项证据表明，异常的 UBE2T 在泛癌中发挥重要作用。从 16 项关于泛素酶的临床试验中收集信息，发现这些分子在泛素-蛋白酶体系统中具有重要作用。需要进一步研究来探索它们作为诊断和预后生物标志物，或作为癌症治疗的上下游和治疗靶点的可行性和有效性。
