Almukhtar Rawaa M, Wood Emily S, Loyal Jameson, Hartman Nina, Fabi Sabrina G
Department of Dermatology, Laser & Cosmetic Dermatology, Scripps Health, San Diego, California.
Westlake Dermatology and Cosmetic Surgery, Austin, Texas.
Dermatol Surg. 2023 Apr 1;49(4):378-382. doi: 10.1097/DSS.0000000000003718. Epub 2023 Feb 24.
More than 90% of women report concerns of cellulite on their skin. Poly- l lactic acid (PLLA-SCA) is a biocompatible, semipermanent, synthetic filler that induces neocollagenesis.
To investigate the safety and efficacy of PLLA-SCA for the treatment of cellulite of the buttock and thigh regions.
This was a prospective, single-center, double-blinded, split-body, clinical trial of 20 women with slight to moderate skin laxity of the buttocks and/or thighs contributing to mild-to-moderate cellulite. Each subject's buttocks and thighs were randomized to receive injections with up to 2 vials of PLLA-SCA or the equivalent volume of bacteriostatic water per treatment area. Subjects received at total of 3 treatments 4 weeks apart and were followed for 330 days.
Treatment of the buttocks with PLLA-SCA resulted in significant reduction of depression depth, improvement in the morphological appearance of the skin, improvement in the grade of skin laxity, and overall improvement in cellulite appearance. Treated thighs showed reduction in the depth and number of depressions and an improvement in overall cellulite appearance. No significant procedure side effects were found.
Poly- l lactic acid offers an effective and safe method for treating cellulite of the buttocks and thighs.
超过90%的女性表示担心自己皮肤上有橘皮组织。聚左旋乳酸（PLLA-SCA）是一种生物相容性好、半永久性的合成填充剂，可诱导新胶原形成。
研究PLLA-SCA治疗臀部和大腿部位橘皮组织的安全性和有效性。
这是一项前瞻性、单中心、双盲、分体的临床试验，纳入20名臀部和/或大腿皮肤轻度至中度松弛导致轻度至中度橘皮组织的女性。将每位受试者的臀部和大腿随机分为接受注射最多2瓶PLLA-SCA或每个治疗区域等量的抑菌水。受试者共接受3次治疗，每次间隔4周，并随访330天。
用PLLA-SCA治疗臀部可显著降低凹陷深度，改善皮肤形态外观，改善皮肤松弛程度，总体改善橘皮组织外观。治疗后的大腿凹陷深度和数量减少，总体橘皮组织外观改善。未发现明显的手术副作用。
聚左旋乳酸为治疗臀部和大腿的橘皮组织提供了一种有效且安全的方法。
