Haddad Alessandra, Avelar Luiz, Fabi Sabrina G, Sarubi Juliana, Somenek Michael, Coimbra Daniel Dal'Asta, Palm Melanie, Durairaj Kalpna K, Somji Munir, Vasconcelos-Berg Roberta, Hanseok Lim, Morlet-Brown Kate, Huang Jeff, Fitzgerald Rebecca, Hexsel Doris, Mao Cheri, Weinberg Felipe, Prygova Inna, Bråsäter Daniel
Hospital Israelita Albert Einstein, Federal University of São Paulo, Rua Bandeira Paulista 726, 8th Floor, São Paulo, SP, 04532-002, Brazil.
A Haddad Medical and Aesthetic Clinics, UNIFESP Federal University of São Paulo, São Paulo, Brazil.
Aesthetic Plast Surg. 2025 Mar;49(5):1507-1517. doi: 10.1007/s00266-024-04499-9. Epub 2024 Nov 26.
Non-facial (body) rejuvenation is a treatment of increasing demand, with patients seeking to harmonize the benefits of rejuvenated facial appearance with other areas of the body. Poly-L-lactic acid (PLLA)-SCA (Sculptra®) has been approved for facial aesthetic uses since 1999 in Europe and since 2009 in the USA and more recently evaluated for the treatment of cellulite of the buttocks and thighs and other body indications. The current evidence base consists largely of prospective observational analyses and case series although systematic evaluations for a number of body areas are underway. Current data support a potential benefit for the use of PLLA-SCA for the aesthetic treatment of the neck, knees, abdomen, hands and upper arms. Improvements in aesthetic appearance (e.g. sagging, wrinkling, dimpling, cellulite) that are sustained over time with minimal side effects can be achieved. Standardization of injection protocols for different body areas is now needed along with the validation of clinical tools that can be used to agree on treatment goals and to evaluate aesthetic improvements over time. A group of international experts in the fields of facial and body aesthetics, plastic surgery and dermatology were selected based on their educational, scientific and publication merits together with clinical experience using PLLA-SCA for body rejuvenation. Here, we provide an evidence-based and expert-led consensus (14 years of off-face treatment experience) on recommendations for appropriate injection protocols for different body sites and evaluation tools when using the biostimulator PLLA-SCA for body aesthetic and rejuvenation procedures.Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
非面部（身体）年轻化治疗的需求日益增加，患者希望使面部年轻化的益处与身体其他部位相协调。聚左旋乳酸（PLLA）-SCA（塑然雅®）自1999年起在欧洲被批准用于面部美容，2009年起在美国获批，最近又被评估用于治疗臀部和大腿的脂肪团及其他身体适应症。目前的证据基础主要由前瞻性观察分析和病例系列组成，尽管针对多个身体部位的系统评估正在进行中。现有数据支持PLLA-SCA用于颈部、膝盖、腹部、手部和上臂的美容治疗可能有益。随着时间的推移，可以实现美学外观的改善（如松弛、皱纹、凹陷、脂肪团），且副作用最小。现在需要对不同身体部位的注射方案进行标准化，同时验证可用于确定治疗目标并随时间评估美学改善情况的临床工具。根据他们在教育、科学和发表成果方面的表现以及使用PLLA-SCA进行身体年轻化治疗的临床经验，挑选了一组面部和身体美学、整形手术及皮肤病学领域的国际专家。在此，我们基于证据并由专家主导（14年非面部治疗经验），就使用生物刺激剂PLLA-SCA进行身体美容和年轻化手术时不同身体部位的适当注射方案及评估工具提供共识。证据级别IV 本刊要求作者为每篇文章指定证据级别。有关这些循证医学评级的完整描述，请参考目录或作者在线指南www.springer.com/00266 。
