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鉴定与免疫和阿尔茨海默病治疗相关的染色质调节因子。

Identification of Chromatin Regulatory Factors Related to Immunity and Treatment of Alzheimer's Disease.

机构信息

Department of Neurosurgery, Binzhou Medical University Hospital, Binzhou, 256603, Shandong, China.

出版信息

J Mol Neurosci. 2023 Mar;73(2-3):85-94. doi: 10.1007/s12031-023-02107-0. Epub 2023 Feb 24.

DOI:10.1007/s12031-023-02107-0
PMID:36826468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10081979/
Abstract

Alzheimer's disease is one of the common neurodegenerative diseases in the elderly, which mainly manifests as progressively severe cognitive impairment, which seriously affects the quality of life of patients. Chromatin regulators have been shown to be associated with a variety of biological processes, and we mainly explore the relationship between chromatin regulators and Alzheimer's disease. Eight hundred seventy chromatin regulators were collected from previous studies, and data related to Alzheimer's disease patients were downloaded from the GEO database. Finally, we screened chromatin regulators related to Alzheimer's disease immunity, established prediction models, and screened related drugs and miRNAs. We screened 160 differentially expressed CRs, constructed an interaction network, obtained 10 hub genes, successfully constructed a prediction model based on immune-related 5 CRs, and obtained 520 related drugs and 3 related miRNA, which provided an idea for the treatment of Alzheimer's disease. Our study identified 5 chromatin regulators related to Alzheimer's disease, which are expected to be new targets for Alzheimer's disease immunotherapy.

摘要

阿尔茨海默病是老年人常见的神经退行性疾病之一，主要表现为进行性严重的认知障碍，严重影响患者的生活质量。染色质调节剂与多种生物学过程有关，我们主要探讨染色质调节剂与阿尔茨海默病的关系。从以往的研究中收集了 870 个染色质调节剂，并从 GEO 数据库中下载了与阿尔茨海默病患者相关的数据。最后，我们筛选了与阿尔茨海默病免疫相关的染色质调节剂，建立了预测模型，并筛选了相关药物和 miRNA。我们筛选了 160 个差异表达的 CR，构建了一个相互作用网络，获得了 10 个枢纽基因，成功构建了基于免疫相关 5 个 CR 的预测模型，并获得了 520 种相关药物和 3 种相关 miRNA，为阿尔茨海默病的治疗提供了思路。我们的研究鉴定了 5 个与阿尔茨海默病相关的染色质调节剂，有望成为阿尔茨海默病免疫治疗的新靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/020b407c572b/12031_2023_2107_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/05b0f1479535/12031_2023_2107_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/80175ff7d460/12031_2023_2107_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/640d6cd17f2a/12031_2023_2107_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/f663364388f3/12031_2023_2107_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/6bd1231aa60d/12031_2023_2107_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/020b407c572b/12031_2023_2107_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/05b0f1479535/12031_2023_2107_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/2ca672ab9bed/12031_2023_2107_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/fde4ab155230/12031_2023_2107_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/80175ff7d460/12031_2023_2107_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/640d6cd17f2a/12031_2023_2107_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/f663364388f3/12031_2023_2107_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/6bd1231aa60d/12031_2023_2107_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9af/10081979/020b407c572b/12031_2023_2107_Fig8_HTML.jpg

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本文引用的文献

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FSH blockade improves cognition in mice with Alzheimer's disease.促卵泡激素阻断可改善阿尔茨海默病小鼠的认知功能。
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Circular RNA SMARCA5 is overexpressed and promotes cell proliferation, migration as well as invasion while inhibits cell apoptosis in bladder cancer.
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