Department of Neurosurgery, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Department of Neurosurgery, Binzhou Central Hospital, Binzhou, Shandong, China.
Sci Rep. 2023 Feb 22;13(1):3084. doi: 10.1038/s41598-023-30236-4.
Parkinson's disease (PD) is a common neurological disorder that causes quiescent tremors, motor delays, depression, and sleep disturbances. Existing treatments can only improve symptoms, not stop progression or cure the disease, but effective treatments can significantly improve patients' quality of life. There is growing evidence that chromatin regulatory proteins (CRs) are involved in a variety of biological processes, including inflammation, apoptosis, autophagy, and proliferation. But the relationship of chromatin regulators in Parkinson's disease has not been studied. Therefore, we aim to investigate the role of CRs in the pathogenesis of Parkinson's disease. We collected 870 chromatin regulatory factors from previous studies and downloaded data on patients with PD from the GEO database. 64 differentially expressed genes were screened, the interaction network was constructed and the key genes with the top 20 scores were calculated. Then we discussed its correlation with the immune function of PD. Finally, we screened potential drugs and miRNAs. Five genes related to the immune function of PD, BANF1, PCGF5, WDR5, RYBP and BRD2, were obtained by using the absolute value of correlation greater than 0.4. And the disease prediction model showed good predictive efficiency. We also screened 10 related drugs and 12 related miRNAs, which provided a reference for the treatment of PD. BANF1, PCGF5, WDR5, RYBP and BRD2 are related to the immune process of Parkinson's disease and can predict the occurrence of Parkinson's disease, which is expected to become a new target for the diagnosis and treatment of Parkinson's disease.
帕金森病（PD）是一种常见的神经退行性疾病，会导致静止性震颤、运动迟缓、抑郁和睡眠障碍。现有的治疗方法只能改善症状，无法阻止疾病进展或治愈疾病，但有效的治疗方法可以显著提高患者的生活质量。越来越多的证据表明染色质调节蛋白（CRs）参与了多种生物学过程，包括炎症、细胞凋亡、自噬和增殖。但是，染色质调节因子在帕金森病中的关系尚未得到研究。因此，我们旨在研究 CRs 在帕金森病发病机制中的作用。我们从之前的研究中收集了 870 个染色质调节因子，并从 GEO 数据库中下载了 PD 患者的数据。筛选出 64 个差异表达基因，构建了相互作用网络，并计算了得分最高的 20 个关键基因。然后我们讨论了它与帕金森病免疫功能的关系。最后，我们筛选了潜在的药物和 miRNA。通过使用相关性绝对值大于 0.4，获得了与 PD 免疫功能相关的 5 个基因，BANF1、PCGF5、WDR5、RYBP 和 BRD2。并且疾病预测模型显示出良好的预测效率。我们还筛选出 10 种相关药物和 12 种相关 miRNA，为 PD 的治疗提供了参考。BANF1、PCGF5、WDR5、RYBP 和 BRD2 与帕金森病的免疫过程有关，可以预测帕金森病的发生，有望成为帕金森病诊断和治疗的新靶点。
