Cilhoroz Burak T, Zaleski Amanda, Taylor Beth, Fernandez Antonio B, Santos Lucas P, Vonk Thijs, Thompson Paul D, Pescatello Linda S
Department of Exercise Science, Falk College of Sports and Human Dynamics, Syracuse University, Syracuse, NY 13244, USA.
Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA.
J Cardiovasc Dev Dis. 2023 Feb 3;10(2):64. doi: 10.3390/jcdd10020064.
Because data are scarce, we examined the relationship between postexercise hypotension (PEH) and heart rate variability (HRV) before and after aerobic exercise training among adults with hypertension. Participants completed a 12 w aerobic training program. Before and after training, they performed a peak graded exercise stress test (GEST) and nonexercise control (CONTROL) and were left attached to an ambulatory BP monitor. Prior to CONTROL, HRV was measured supine for 5 min using a 12-lead electrocardiogram (ECG). The participants ( = 18) were middle-aged (52.1 ± 11.7 y) and 50% men with hypertension (131.7 ± 9.8/85.9 ± 8.5 mmHg) and obesity (30.0 ± 3.7 kg·m). Before training, ambulatory systolic BP (ASBP) and diastolic ABP (ADBP) decreased by 3.2 ± 2.1 mmHg and 2.5 ± 1.5 mmHg, respectively, from baseline after the GEST versus CONTROL ( < 0.05). After training, ASBP tended to decrease by 3.5 ± 2.2 mmHg ( = 0.055) and ADBP decreased by 1.7 ± 2.5 mmHg ( = 0.001) from baseline after the GEST versus CONTROL. Before training, HRV high frequency (HFms) (β = -0.441), age (β = 0.568), and resting SBP (β = 0.504) accounted for 66.8% of the ASBP response ( = 0.001), whereas the low frequency (LF)/HF ratio (β = 0.516) and resting DBP (β = 0.277) accounted for 35.7% of the ADBP response ( = 0.037). After training, the standard deviation of NN intervals (SDNN) (β = -0.556), age (β = 0.506), and resting SBP (β = 0.259) accounted for 60.7% of the ASBP response ( = 0.004), whereas SDNN (β = -0.236) and resting DBP (β = 0.785) accounted for 58.5% of the ADBP response ( = 0.001). Our preliminary findings show that adults with hypertension and parasympathetic suppression (i.e., lower SDNN and HFms and higher LF/HF) may elicit PEH to the greatest degree independent of training status versus adults with parasympathetic predominance, suggesting that resting HRV may be an important determinant of PEH.
由于数据匮乏，我们研究了高血压成人有氧运动训练前后运动后低血压（PEH）与心率变异性（HRV）之间的关系。参与者完成了一项为期12周的有氧训练计划。在训练前后，他们进行了峰值分级运动应激试验（GEST）和非运动对照（CONTROL），并一直佩戴动态血压监测仪。在进行CONTROL之前，使用12导联心电图（ECG）仰卧位测量HRV 5分钟。参与者（n = 18）为中年（52.1±11.7岁），50%为男性，患有高血压（131.7±9.8/85.9±8.5 mmHg）和肥胖（30.0±3.7 kg·m²）。训练前，与CONTROL相比，GEST后动态收缩压（ASBP）和动态舒张压（ADBP）分别较基线下降3.2±2.1 mmHg和2.5±1.5 mmHg（P < 0.05）。训练后，与CONTROL相比，GEST后ASBP倾向于较基线下降3.5±2.2 mmHg（P = 0.055），ADBP下降1.7±2.5 mmHg（P = 0.001）。训练前，HRV高频（HFms）（β = -0.441）、年龄（β = 0.568）和静息收缩压（β = 0.504）占ASBP反应的66.8%（P = 0.001），而低频（LF）/HF比值（β = 0.516）和静息舒张压（β = 0.277）占ADBP反应的35.7%（P = 0.037）。训练后，NN间期标准差（SDNN）（β = -0.556）、年龄（β = 0.506）和静息收缩压（β = 0.259）占ASBP反应的60.7%（P = 0.004），而SDNN（β = -0.236）和静息舒张压（β = 0.785）占ADBP反应的58.5%（P = 0.001）。我们的初步研究结果表明，与副交感神经占优势的成年人相比，患有高血压和副交感神经抑制（即较低的SDNN和HFms以及较高的LF/HF）的成年人可能在最大程度上引发PEH，而与训练状态无关，这表明静息HRV可能是PEH的一个重要决定因素。
