Kleinnibbelink Geert, Stens Niels A, Fornasiero Alessandro, Speretta Guilherme F, Van Dijk Arie P J, Low David A, Oxborough David L, Thijssen Dick H J
Department of Physiology.
Department of Cardiology, Research Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Medicine (Baltimore). 2020 Sep 25;99(39):e22411. doi: 10.1097/MD.0000000000022411.
Acute exercise leads to an immediate drop in blood pressure (BP), also called post-exercise hypotension (PEH). Exercise in hypoxia is related to additional vasodilation, potentially contributing to more profound PEH. Therefore, we investigated the impact of hypoxia versus normoxia on the magnitude of PEH. Second, we examined whether these changes in PEH relate to the BP-lowering effects of 12-week exercise training under hypoxia.
In this prospective study, 21 healthy individuals (age 22.2 ± 3.0 years, 14 male) performed a 45-minute high-intensity running exercise on 2 different days in a random order, under hypoxia (fraction of inspired oxygen 14.5%) and normoxia (fraction of inspired oxygen 20.9%). BP was examined pre-exercise (t = 0) and at t = 15, t = 30, t = 45, and t = 60 minutes post-exercise. Afterward, subjects took part in a 12-week hypoxic running exercise training program. Resting BP was measured before and after the 12-week training program.
Acute exercise induced a significant decrease in systolic BP (systolic blood pressure [SBP], P = .001), but not in diastolic BP (diastolic blood pressure [DBP], P = .113). No significant differences were observed in post-exercise BP between hypoxic and normoxic conditions (SBP, P = .324 and DBP, P = .204). Post-exercise changes in SBP, DBP, and mean arterial pressure significantly correlated to the 12-week exercise training-induced changes in SBP (r = 0.557, P = .001), DBP (r = 0.615, P < .001), and mean arterial pressure (r = 0.458, P = .011).
Our findings show that hypoxia does not alter the magnitude of PEH in healthy individuals, whilst PEH relates to the BP-lowering effects of exercise. These data highlight the strong link between acute and chronic changes in BP.
急性运动导致血压（BP）立即下降，也称为运动后低血压（PEH）。低氧环境下的运动与额外的血管舒张有关，可能导致更严重的PEH。因此，我们研究了低氧与常氧对PEH程度的影响。其次，我们研究了这些PEH的变化是否与低氧环境下12周运动训练的降压效果有关。
在这项前瞻性研究中，21名健康个体（年龄22.2±3.0岁，14名男性）在低氧（吸入氧分数14.5%）和常氧（吸入氧分数20.9%）条件下，随机顺序在2个不同日期进行了45分钟的高强度跑步运动。在运动前（t = 0）以及运动后15分钟、30分钟、45分钟和60分钟测量血压。之后，受试者参加了为期12周的低氧跑步运动训练计划。在12周训练计划前后测量静息血压。
急性运动导致收缩压（SBP）显著下降（收缩压，P = 0.001），但舒张压（DBP）无显著下降（舒张压，P = 0.113）。低氧和常氧条件下运动后的血压无显著差异（SBP，P = 0.324；DBP，P = 0.204）。运动后SBP、DBP和平均动脉压的变化与12周运动训练引起的SBP（r = 0.557，P = 0.001）、DBP（r = 0.615，P < 0.001）和平均动脉压（r = 0.458，P = 0.011）的变化显著相关。
我们的研究结果表明，低氧不会改变健康个体的PEH程度，而PEH与运动的降压效果有关。这些数据突出了血压急性和慢性变化之间的紧密联系。
