Pigoń Katarzyna, Tomecka Natalia, Korner Dominika, Pękała Maciej, Grzegorczyn Sławomir, Konka Adam, Nowalany-Kozielska Ewa, Tomasik Andrzej
II Department of Cardiology in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Students' Scientific Group at II Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
J Cardiovasc Dev Dis. 2023 Feb 6;10(2):69. doi: 10.3390/jcdd10020069.
Although the routine use of thrombus aspiration is not recommended, the thrombectomy technique still might be considered for a selected population of patients. Therefore, the assessment of the effectiveness of commercially available thrombectomy devices is still clinically relevant.
Here, we present an in vitro comparison of several different types of catheters that can be used for thrombus aspiration or removal.
Through the removal of 6 h and 24 h human blood clots in an in vitro model, four catheters were compared: the Launcher, Pronto V4, Vasco+ and the stent-retriever Catchview. The aspiration efficacy was expressed as a percentage of the initial thrombus weight. The effectiveness of the patient's aspiration was dependent on the time of thrombus formation and was significantly higher for a thrombus formed over 24 h (58.5 ± 26.5%) than for one formed over 6 h (48.0 ± 22.5%; < 0.001). In the presented in vitro model, Pronto V4 and Launcher showed the highest efficiency.
Large-bore aspiration catheters were found to be more effective than narrow-bore catheters or stent-retrievers in an in vitro model of thrombus removal. The thrombus aspiration efficacy increases with longer thrombus formation times.
尽管不建议常规使用血栓抽吸术，但对于特定患者群体仍可考虑采用血栓切除术技术。因此，评估市售血栓切除装置的有效性在临床上仍具有重要意义。
在此，我们对几种可用于血栓抽吸或清除的不同类型导管进行体外比较。
在体外模型中通过去除6小时和24小时的人体血凝块，对四种导管进行比较：Launcher、Pronto V4、Vasco+和支架取栓器Catchview。抽吸效果以初始血栓重量的百分比表示。患者抽吸的有效性取决于血栓形成时间，24小时以上形成的血栓（58.5±26.5%）的抽吸效果显著高于6小时以上形成的血栓（48.0±22.5%；P<0.001）。在本体外模型中，Pronto V4和Launcher显示出最高效率。
在体外血栓清除模型中，发现大口径抽吸导管比小口径导管或支架取栓器更有效。血栓抽吸效果随血栓形成时间延长而增加。
