Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, Illinois, United States of America.
Institute for Health Research and Policy, University of Illinois Chicago, Chicago, Illinois, United States of America.
PLoS One. 2023 Feb 24;18(2):e0280211. doi: 10.1371/journal.pone.0280211. eCollection 2023.
Those with mild cognitive impairment (MCI), a precursor to dementia, have a gut microbiome distinct from healthy individuals, but this has only been shown in healthy individuals, not in those exhibiting several risk factors for dementia. Using amplicon 16S rRNA gene sequencing in a case-control study of 60 older (ages 55-76), obese, predominately female, African American adults, those with MCI (cases) had different gut microbiota profiles than controls. While microbial community diversity was similar between cases and controls, the abundances of specific microbial taxa weren't, such as Parabacteroides distasonis (lower in cases) and Dialister invisus (higher in cases). These differences disappeared after adjusting for markers of oxidative stress and systemic inflammation. Cognitive scores were positively correlated with levels of Akkermansia muciniphila, a bacterium associated with reduced inflammation. Our study shows that gut microbial composition may be associated with inflammation, oxidative stress, and MCI in those at high risk for dementia.
患有轻度认知障碍 (MCI) 的人，也就是痴呆症的前兆，其肠道微生物组与健康个体不同，但这仅在健康个体中得到了证实，而在表现出多种痴呆症风险因素的个体中尚未得到证实。在一项针对 60 名年龄在 55-76 岁、肥胖、以女性为主、非裔美国成年人的病例对照研究中，使用扩增子 16S rRNA 基因测序，与对照组相比，患有 MCI（病例）的个体的肠道微生物群特征不同。虽然病例组和对照组之间的微生物群落多样性相似，但特定微生物类群的丰度不同，例如 Parabacteroides distasonis（病例组中较低）和 Dialister invisus（病例组中较高）。这些差异在调整了氧化应激和全身炎症的标志物后消失了。认知评分与 Akkermansia muciniphila 的水平呈正相关，Akkermansia muciniphila 是一种与炎症减轻相关的细菌。我们的研究表明，肠道微生物组成可能与炎症、氧化应激和高痴呆风险人群的 MCI 有关。
