Center for Rehabilitation Medicine, Department of Psychiatry, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, 158 Shangtang Rd, Hangzhou, 310014, Zhejiang, People's Republic of China.
Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing, 210095, Jiangsu Province, China.
Lipids Health Dis. 2024 Feb 29;23(1):64. doi: 10.1186/s12944-024-02056-6.
Extensive evidence demonstrates correlations among gut microbiota, lipid metabolism and cognitive function. However, there is still a lack of researches in the field of late-life depression (LLD). This research targeted at investigating the relationship among gut microbiota, lipid metabolism indexes, such as total free fatty acids (FFAs), and cognitive functions in LLD.
Twenty-nine LLD patients from the Cognitive Outcome Cohort Study of Depression in Elderly were included. Cognitive functions were estimated through the Chinese version of Montreal Cognitive Assessment (MoCA). Blood samples were collected to evaluate serum lipid metabolism parameters. Fecal samples were evaluated for gut microbiota determination via 16S rRNA sequencing. Spearman correlation, linear regression and mediation analysis were utilized to explore relationship among gut microbiota, lipid metabolism and cognitive function in LLD patients.
Spearman correlation analysis revealed significant correlations among Akkermansia abundance, total Free Fatty Acids (FFAs) and MoCA scores (P < 0.05). Multiple regression indicated Akkermansia and total FFAs significantly predicted MoCA scores (P < 0.05). Mediation analysis demonstrated that the correlation between decreased Akkermansia relative abundance and cognitive decline in LLD patients was partially mediated by total FFAs (Bootstrap 95%CI: 0.023-0.557), accounting for 43.0% of the relative effect.
These findings suggested a significant relationship between cognitive functions in LLD and Akkermansia, as well as total FFAs. Total FFAs partially mediated the relationship between Akkermansia and cognitive functions. These results contributed to understanding the gut microbial-host lipid metabolism axis in the cognitive function of LLD.
大量证据表明肠道微生物群、脂代谢和认知功能之间存在关联。然而，在老年期抑郁症（LLD）领域，相关研究仍然较少。本研究旨在探讨 LLD 患者肠道微生物群、脂代谢指标（如总游离脂肪酸（FFAs））与认知功能之间的关系。
纳入来自认知结局队列研究的 29 名 LLD 患者。通过蒙特利尔认知评估（MoCA）中文版评估认知功能。采集血样评估血清脂代谢参数。通过 16S rRNA 测序评估粪便样本中的肠道微生物群。采用 Spearman 相关分析、线性回归和中介分析探讨 LLD 患者肠道微生物群、脂代谢与认知功能之间的关系。
Spearman 相关分析显示 Akkermansia 丰度、总游离脂肪酸（FFAs）与 MoCA 评分之间存在显著相关性（P<0.05）。多元回归分析表明 Akkermansia 和总 FFAs 显著预测 MoCA 评分（P<0.05）。中介分析表明 Akkermansia 相对丰度降低与 LLD 患者认知能力下降之间的相关性部分由总 FFAs 介导（Bootstrap 95%CI：0.023-0.557），占相对效应的 43.0%。
这些发现表明 LLD 患者认知功能与 Akkermansia 和总 FFAs 之间存在显著关系。总 FFAs 部分介导了 Akkermansia 与认知功能之间的关系。这些结果有助于理解 LLD 认知功能中肠道微生物群-宿主脂代谢轴。
