从南海软珊瑚 Sinularia scabra 中发现不常见的萜类化合物。
Discovery of uncommon terpenoids from the South China Sea soft coral Sinularia scabra.
机构信息
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, 315800, Zhejiang, China.
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
出版信息
Phytochemistry. 2023 May;209:113616. doi: 10.1016/j.phytochem.2023.113616. Epub 2023 Feb 23.
Sinulatones A and B, presented as the unusual carbon skeleton with bicyclo[4.5.0] system, two undescribed sesquiterpenoids, namely sinulalides A and B, along with eight known terpenoids, were isolated from the South China Sea soft coral Sinularia scabra. The structures and stereochemistry of these compounds were determined based on extensive spectroscopic data analyses, and computer-assisted methods, including the quantum mechanical-nuclear magnetic resonance (QM-NMR) and TDDFT-ECD calculations. In bioassay, sinulatones A and B showed inhibitory activity against osteoclast precursor cells, with IC values of 16.8 and 5.8 μM, respectively.
从南海软珊瑚 Sinularia scabra 中分离得到了两个结构新颖的倍半萜类化合物 sinulalides A 和 B，它们的碳骨架呈现出双环[4.5.0]系统，此外还分离得到了 8 个已知萜类化合物。通过广泛的光谱数据分析和计算机辅助方法，包括量子力学-核磁共振（QM-NMR）和 TDDFT-ECD 计算，确定了这些化合物的结构和立体化学。在生物测定中，sinulatones A 和 B 对破骨细胞前体细胞具有抑制活性，IC 值分别为 16.8 和 5.8 μM。
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