State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Nano Science and Technology Institute, University of Science and Technology of China, Suzhou, China.
Nat Prod Res. 2022 Jul;36(13):3324-3330. doi: 10.1080/14786419.2020.1855645. Epub 2020 Dec 24.
A new diterpenoid with an unusual capnosane skeleton, sinuhumilol A (), alone with twelve known diverse compounds (), were isolated from the South China Sea soft coral Their structures and stereochemistry were elucidated by extensive spectroscopic analysis, quantum chemical calculations, and/or by the comparison of the spectroscopic data with those reported in the literature. In bioassay, compound exhibited interesting specific cytotoxicity against the human colon adenocarcinoma cell line HT-29 with IC value of 12.5 M.
从南海软珊瑚中分离得到了一个具有不寻常碳氮烷骨架的新二萜化合物 sinuhumilol A ()， 以及十二个已知的不同化合物 ()。通过广泛的光谱分析、量子化学计算和/或通过与文献报道的光谱数据进行比较，确定了它们的结构和立体化学。在生物测定中，化合物对人结肠腺癌细胞系 HT-29 表现出有趣的特异性细胞毒性，IC 值为 12.5 μM。
