西努斯卡利德A：一种来自中国南海软珊瑚的具有8/8稠合碳骨架的抗病毒降碳环类化合物 。
Sinuscalide A: An Antiviral Norcembranoid with an 8/8-Fused Carbon Scaffold from the South China Sea Soft Coral .
作者信息
Liu Jing, Tang Qi, Huang Jian, Li Te, Ouyang Han, Lin Wen-Han, Yan Xiao-Jun, Yan Xia, He Shan
机构信息
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, Zhejiang 315800, China.
Department of Microbiology, The Key Laboratory of Microbiology and Parasitology of Anhui Province, The Key Laboratory of Zoonoses of High Institutions in Anhui, School of Basic Medical Sciences, Anhui Medical University, Hefei 230031, China.
出版信息
J Org Chem. 2022 Aug 5;87(15):9806-9814. doi: 10.1021/acs.joc.2c00784. Epub 2022 Jul 19.
Sinuscalide A (), featuring an uncommon 8/8-fused carbon scaffold, three new norditerpenes, sinuscalides B-D (-), and sinuscatone A (), with a 5/4/9 tricyclic carbon ring system, along with four known compounds were isolated from the South China Sea soft coral . The structures of the new compounds were established by extensive spectroscopic analysis, X-ray diffraction, and electronic circular dichroism (ECD). A plausible biosynthetic pathway for was proposed. In a bioassay, compound showed antiviral activity against human enterovirus EV71 (IC = 5.0 μM) and an inhibitory effect against RANKL-induced osteoclastogenesis (92.3% inhibition at 10 μM). Compound exhibited mild inhibition against and (MIC 16 μg/mL).
从中国南海软珊瑚中分离出了具有罕见的8/8稠合碳骨架的正弦环肽A（）、三种新的降二萜类化合物——正弦环肽B-D（-）以及具有5/4/9三环碳环系统的正弦酮A（），还有四种已知化合物。通过广泛的光谱分析、X射线衍射和电子圆二色光谱（ECD）确定了新化合物的结构。提出了一种关于的合理生物合成途径。在生物活性测定中，化合物对人肠道病毒EV71表现出抗病毒活性（IC = 5.0 μM），并且对RANKL诱导的破骨细胞生成具有抑制作用（在10 μM时抑制率为92.3%）。化合物对和表现出轻度抑制作用（MIC为16 μg/mL）。
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