色氨酸可利用性改变对正常男性乙醇中毒的影响。

The influence of altered tryptophan availability on ethanol intoxication in normal men.

作者信息

Zacchia C, Pihl R O, Young S, Ervin F R

机构信息

Department of Psychology, McGill University, Montreal, Canada.

出版信息

J Stud Alcohol. 1987 Nov;48(6):535-40. doi: 10.15288/jsa.1987.48.535.

DOI:10.15288/jsa.1987.48.535

PMID:3682827

Abstract

Because of evidence that altered 5-hydroxytryptamine function may modulate ethanol intoxication, we investigated this in normal social drinkers. Using amino acid mixtures, 5-hydroxytryptamine was influenced by altering levels of its precursor tryptophan. Neither raising nor lowering tryptophan affected alcohol intoxication as measured by a self-report scale and memory and motor tasks. Our data do not support the idea that 5-hydroxytryptamine can modulate alcohol-induced intoxication.

摘要

由于有证据表明5-羟色胺功能改变可能会调节乙醇中毒，我们在正常社交饮酒者中对此进行了研究。使用氨基酸混合物，通过改变其前体色氨酸的水平来影响5-羟色胺。无论是提高还是降低色氨酸水平，通过自我报告量表以及记忆和运动任务测量，均未影响酒精中毒。我们的数据不支持5-羟色胺可调节酒精所致中毒这一观点。