Hospital General Universitario Morales Meseguer (Murcia), Universidad de Murcia, Spain.
Complejo Hospitalario Universitario de León, Spain.
Actas Dermosifiliogr. 2023 May;114(5):377-381. doi: 10.1016/j.ad.2023.02.004. Epub 2023 Feb 23.
Shellac is a known allergen present mainly in cosmetics used on the eyelids and lips, although new sources of exposure have recently been described. Our objective was to assess the use of shellac as a contact allergen in Spain and the clinical profile of patients allergic to shellac.
This retrospective cross-sectional study included patients patch tested for shellac between 2018 and 2021 from the Spanish Registry of Contact Dermatitis and Cutaneous Allergy (REIDAC).
A total of 980 patients were patch tested for shellac (20% in ethanol), and 37 (3.77%, 95% confidence interval [CI], 2.58-3.97%) showed positive results. Most of these patients were tested for shellac due to a suspicion of cosmetic contact dermatitis. Seven patients with present relevance were found, five with relation to cosmetics, and the other two with an occupational background of food handling. The reaction index for shellac was 0.51 and the positivity ratio was 67.56% (95% CI, 52.48-82.65%).
Shellac appears to be a prevalent allergen in patients with suspected contact dermatitis related with cosmetics or foodstuff. However, further studies are needed to validate its use in other patients.
虫胶是一种已知的过敏原，主要存在于用于眼睑和嘴唇的化妆品中，尽管最近已经描述了新的接触源。我们的目的是评估在西班牙虫胶作为接触过敏原的使用情况以及对虫胶过敏的患者的临床特征。
这项回顾性横断面研究包括 2018 年至 2021 年期间在西班牙接触性皮炎和过敏登记处（REIDAC）进行虫胶斑贴试验的患者。
共有 980 名患者接受了虫胶（20%乙醇溶液）斑贴试验，其中 37 名（3.77%，95%置信区间[CI]：2.58-3.97%）结果阳性。这些患者中的大多数因怀疑化妆品接触性皮炎而接受了虫胶斑贴试验。发现了 7 名具有当前相关性的患者，其中 5 名与化妆品有关，另外 2 名与食品处理的职业背景有关。虫胶的反应指数为 0.51，阳性率为 67.56%（95%CI：52.48-82.65%）。
虫胶似乎是怀疑与化妆品或食品有关的接触性皮炎患者的常见过敏原。然而，需要进一步的研究来验证其在其他患者中的使用。
