OTA 单次口服染毒对德州公驴的毒代动力学研究。
Toxicokinetics of a Single Oral Dose of OTA on Dezhou Male Donkeys.
机构信息
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
National Engineering Research Center for Gelatin-Based Traditional Chinese Medicine, Dong-E-E-Jiao Co., Ltd., Liaocheng 252201, China.
出版信息
Toxins (Basel). 2023 Jan 18;15(2):88. doi: 10.3390/toxins15020088.
Ochratoxin (OTA) is widely present in a wide range of foods and feeds, causing adverse effects on animals and humans. This study aims to explore the toxicokinetics of OTA-contaminated materials on the Dezhou male donkey. Donkeys received a single orally dose of 2500 μg OTA/kg BW, obtained from culture material. The concentrations of OTA in plasma collected at 0, 5, 10, 15, 20, 30, 45 min, and at 1, 1.5, 2, 3, 6, 9, 12, 24, 48, 72, 96 and 120 h were detected by HPLC. OTA eliminated in urine and feces were quantified at 6-h intervals up to 24 h and then at 4-h intervals up to 120 h. The results suggested that the maximum concentration of OTA in plasma was observed at 12 h after administration, with a mean value of 10.34 μg/mL. The total excretion in both urine and feces was about 10% of the intake until 120 h.
赭曲霉毒素（OTA）广泛存在于多种食品和饲料中，对动物和人类具有不良影响。本研究旨在探索受 OTA 污染物质对德州公驴的毒代动力学。驴接受了单次口服 2500μg OTA/kgBW 的剂量，来源于培养物。通过 HPLC 检测了在 0、5、10、15、20、30、45 分钟和 1、1.5、2、3、6、9、12、24、48、72、96 和 120 小时采集的血浆中 OTA 的浓度。在 24 小时内每 6 小时和之后每 4 小时定量检测尿液和粪便中 OTA 的排泄量，直至 120 小时。结果表明，给药后 12 小时观察到血浆中 OTA 的最大浓度，平均值为 10.34μg/mL。在 120 小时内，尿液和粪便中的总排泄量约为摄入量的 10%。
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