Provincial Key Laboratory of Biotechnology, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an 710069, China.
Toxins (Basel). 2023 Feb 17;15(2):164. doi: 10.3390/toxins15020164.
Toxin-antitoxin (TA) systems are typically composed of a stable toxin and a labile antitoxin; the latter counteracts the toxicity of the former under suitable conditions. TA systems are classified into eight types based on the nature and molecular modes of action of the antitoxin component so far. The 10 pairs of TA systems discovered and experimentally characterised in are type II TA systems. Type II TA systems have various physiological functions, such as virulence and biofilm formation, protection host against antibiotics, persistence, plasmid maintenance, and prophage production. Here, we review the type II TA systems of , focusing on their biological functions and regulatory mechanisms, providing potential applications for the novel drug design.
毒素-抗毒素（TA）系统通常由稳定的毒素和不稳定的抗毒素组成；在合适的条件下，后者会中和前者的毒性。到目前为止，根据抗毒素成分的性质和分子作用模式，TA 系统已被分为八种类型。在中发现并经过实验表征的 10 对 TA 系统属于 II 型 TA 系统。II 型 TA 系统具有多种生理功能，如毒力和生物膜形成、保护宿主免受抗生素影响、持久性、质粒维持和噬菌体产生。在这里，我们综述了的 II 型 TA 系统，重点关注它们的生物学功能和调控机制，为新型药物设计提供了潜在的应用。
