从急性肾小球肾炎患者分离出的链球菌细胞外产物中一种蛋白质的出现情况。
The occurrence of a protein in the extracellular products of streptococci isolated from patients with acute glomerulonephritis.
作者信息
Villarreal H, Fischetti V A, van de Rijn I, Zabriskie J B
出版信息
J Exp Med. 1979 Feb 1;149(2):459-72. doi: 10.1084/jem.149.2.459.
Abstract
The present report compares the extracellular proteins of streptococci by sodium dodecyl sulfate polyacrylamide electrophoresis. A marked variation in the streptococcal extracellualr proteins (SEP) of different strains was detected, even in strains of similar serotypes. It was possible, however, to identify a single protein band that occurred predominantly in the SEP of strains isolated from patients with acute poststreptococcal glomerulonephritis (APSGN). This protein was generally not produced by streptococci obtained from patients without this disease. It appears to be immunologically similar in the various serotypes of streptococci isolated from patients with APSGN and can be demonstrated by immunofluorescence techniques to be present in the glomeruli of these patients.
摘要
本报告通过十二烷基硫酸钠聚丙烯酰胺电泳对链球菌的细胞外蛋白进行了比较。即使在血清型相似的菌株中，也检测到不同菌株的链球菌细胞外蛋白（SEP）存在显著差异。然而，有可能鉴定出一条主要出现在急性链球菌感染后肾小球肾炎（APSGN）患者分离菌株的SEP中的单一蛋白带。这种蛋白通常不由未患此病患者分离出的链球菌产生。从APSGN患者分离出的不同血清型链球菌中，该蛋白在免疫上似乎相似，并且通过免疫荧光技术可以证明其存在于这些患者的肾小球中。
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