链球菌感染的分析。VI. 关于可用人抗体检测到的细胞外抗原的免疫电泳观察。
The analysis of streptococcal infections. VI. Immunoelectrophoretic observations on extracellular antigens detectable with human antibodies.
作者信息
HALBERT S P, KEATINGE S L
出版信息
J Exp Med. 1961 Jun 1;113(6):1013-28. doi: 10.1084/jem.113.6.1013.
Abstract
It has been found by immunoelectrophoresis, that Group A streptococci release at least 20 distinct extracellular antigens in human tissues, as judged by naturally occurring antibodies present in normal pooled human gamma globulin. Several of these precipitin arcs have been identified with streptococcal antigens previously purified by electrophoresis and chromatography. Human gamma globulin, as well as several rheumatic fever sera, were shown to be remarkably potent in antistreptococcal antibodies, when compared to four horse antibody concentrates obtained by hyperimmunization with several streptococcal filtrates. A Group C streptococcal culture concentrate revealed 8 or 9 antigens for which corresponding antibodies were present in human gamma globulin.
摘要
通过免疫电泳发现，根据正常人混合γ球蛋白中天然存在的抗体判断，A组链球菌在人体组织中释放至少20种不同的细胞外抗原。其中几条沉淀弧已被鉴定为先前通过电泳和色谱法纯化的链球菌抗原。与通过用几种链球菌滤液进行超免疫获得的四种马抗体浓缩物相比，人γ球蛋白以及几种风湿热血清显示出具有显著效力的抗链球菌抗体。一种C组链球菌培养浓缩物显示出8或9种抗原，人γ球蛋白中存在针对这些抗原的相应抗体。
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The use of precipitin analysis in agar for the study of human streptococcal infections. I. Oudin technic.琼脂中沉淀素分析在人类链球菌感染研究中的应用。I. 乌丹技术。
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