Hou Junhui, Zhang Gong, Wang Xia, Wang Yuan, Wang Kefeng
Department of Urology, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning, China.
Department of General Surgery, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning, China.
Biomark Res. 2023 Feb 24;11(1):23. doi: 10.1186/s40364-023-00467-8.
Chemotherapy is one of the most important treatments for cancer therapy. However, chemotherapy resistance is a big challenge in cancer treatment. Due to chemotherapy resistance, drugs become less effective or no longer effective at all. In recent years, long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been found to be associated with the development of chemotherapy resistance, suggesting that MALAT1 may be an important target to overcome chemotherapy resistance. In this review, we introduced the main mechanisms of chemotherapy resistance associated with MALAT1, which may provide new approaches for cancer treatment.
化疗是癌症治疗中最重要的治疗方法之一。然而，化疗耐药性是癌症治疗中的一个重大挑战。由于化疗耐药性，药物变得效果较差或完全不再有效。近年来，长链非编码RNA转移相关肺腺癌转录本1（MALAT1）已被发现与化疗耐药性的产生有关，这表明MALAT1可能是克服化疗耐药性的一个重要靶点。在这篇综述中，我们介绍了与MALAT1相关的化疗耐药性的主要机制，这可能为癌症治疗提供新的方法。
