Huang Kuo-Ching, Chang Yu-Ting, Pranata Rosita, Cheng Yung-Hsuan, Chen Yu-Chi, Kuo Ping-Chung, Huang Yi-Hsuan, Tzen Jason T C, Chen Rong-Jane
Division of Nephrology, Department of Internal Medicine, Chi Mei Hospital, Tainan 736, Taiwan.
Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Biology (Basel). 2023 Feb 17;12(2):329. doi: 10.3390/biology12020329.
Hyperuricemia, an abnormally high level of blood uric acid, is a major risk factor for gout. Although xanthine oxidase inhibitors were clinically used to lower blood uric acid level, the concerned side effects restricted their utilization. In this study, strictinin, an abundant polyphenol in Pu'er tea, was evaluated for its preventive effects on hyperuricemia. The results showed that the xanthine oxidase activity, uric acid production, and inflammation in AML12 mouse hepatocytes treated with xanthine were significantly reduced by the supplementation of strictinin. Detailed analyses revealed that strictinin inhibited xanthine-induced NLRP3 inflammasome activation. Consistently, the elevated blood uric acid level and the enhanced xanthine oxidase activity in mice treated with potassium oxonate were effectively diminished by strictinin supplementation. Moreover, for the first time, strictinin was found to promote healthy gut microbiota. Overall, strictinin possesses a great potential to be utilized as a functional ingredient for the prevention of hyperuricemia.
高尿酸血症是指血液中尿酸水平异常升高，是痛风的主要危险因素。尽管黄嘌呤氧化酶抑制剂临床上用于降低血尿酸水平，但其相关副作用限制了它们的应用。在本研究中，对普洱茶中含量丰富的多酚化合物丁香亭预防高尿酸血症的作用进行了评估。结果表明，补充丁香亭可显著降低用黄嘌呤处理的AML12小鼠肝细胞中的黄嘌呤氧化酶活性、尿酸生成及炎症反应。详细分析显示，丁香亭可抑制黄嘌呤诱导的NLRP3炎性小体激活。同样，补充丁香亭可有效降低用氧嗪酸钾处理的小鼠升高的血尿酸水平及增强的黄嘌呤氧化酶活性。此外，首次发现丁香亭可促进肠道有益微生物群生长。总体而言，丁香亭具有作为预防高尿酸血症功能性成分的巨大潜力。
