Liao Man-Hua, Wang Xiu-Ru, Hsu Wei-Li, Tzen Jason T C
Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung, Taiwan.
Graduate Institute of Microbiology and Public Health, National Chung-Hsing University, Taichung, Taiwan.
J Dent Sci. 2021 Oct;16(4):1331-1334. doi: 10.1016/j.jds.2021.05.011. Epub 2021 Jun 11.
Cariogenic bacteria, such as and , are main pathogens responsible for human dental caries. Pu'er tea is empirically observed to prevent tooth decay. Besides caffeine and catechins commonly found in oolong tea, strictinin is also found as an abundant phenolic compound in Pu'er tea. Infusion of Pu'er tea as well as single compound, strictinin, caffeine or (-)-epigallocatechin gallate (EGCG) was examined for its inhibitory effects on and . Relatively weak inhibition of bacterial growth was observed for these Pu'er tea constituents. However, biofilm formation of or was strongly prevented by the infusion of Pu'er tea as well as by strictinin or EGCG, but not caffeine. Relatively, strictinin showed a higher potency than EGCG to prevent biofilm formation. Anti-caries effect of Pu'er tea seems to be resulted from the prevention of biofilm formation of cariogenic bacteria mainly by strictinin and catechins.
致龋菌，如变形链球菌和远缘链球菌，是导致人类龋齿的主要病原体。据经验观察，普洱茶可预防龋齿。除了乌龙茶中常见的咖啡因和儿茶素外，普洱茶中还含有丰富的酚类化合物丁香亭。研究了普洱茶茶汤以及单一化合物丁香亭、咖啡因或（-）-表没食子儿茶素没食子酸酯（EGCG）对变形链球菌和远缘链球菌的抑制作用。这些普洱茶成分对细菌生长的抑制作用相对较弱。然而，普洱茶茶汤以及丁香亭或EGCG能强烈抑制变形链球菌或远缘链球菌生物膜的形成，但咖啡因无此作用。相对而言，丁香亭在预防生物膜形成方面比EGCG表现出更高的效力。普洱茶的防龋作用似乎主要是由于丁香亭和儿茶素对致龋菌生物膜形成的预防作用。
