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带有吻合术的闭塞动脉模型血流动力学场的计算研究

Computational Study of Hemodynamic Field of an Occluded Artery Model with Anastomosis.

作者信息

Parissis Panagiotis, Romeos Alexandros, Giannadakis Athanasios, Kalarakis Alexandros, Peroulis Michail

机构信息

Department of Mechanical Engineering and Aeronautics, Laboratory of Applied Thermodynamics, University of Patras, 26504 Patras, Greece.

Department of Mechanical Engineering, Laboratory of Heating Cooling and Refrigeration, University of the Peloponnese, 26334 Patras, Greece.

出版信息

Bioengineering (Basel). 2023 Jan 21;10(2):146. doi: 10.3390/bioengineering10020146.

Abstract

In this research work, the hemodynamic field of an occluded artery with anastomosis by means of computational simulation has been studied. The main objective of the current study is the investigation of 3D flow field phenomena in the by-pass region and the effect of the bypass graft to stenosis volume flow ratio on their formation. The anastomosis type was end-to-side with a 45° angle, while stenosis imposed a 75% area blockage of the aorta vessel and the total volume flow was 220 lt/h. The computational study of the flow field was utilized via a laminar flow model and three turbulence models (k-ε RNG, standard k-ω, and k-ω SST). Numerical results were compared qualitatively with experimental visualizations carried out under four different flow conditions, varying according to the flow ratio between the stenosis and the anastomotic graft. Comparison between computational results and experimental visualization findings exhibited a good agreement. Results showed that SST k-ω turbulence models reproduce better visually obtained flow patterns. Furthermore, cross-sectional velocity distributions demonstrated two distinct flow patterns down the bypass graft, depending on the flow ratio. Low values of flow ratio are characterized by fluid rolling up, whereas for high values fluid volume twisting was observed. Finally, areas with low wall shear stresses were mapped, as these are more prone to postoperative degradation of the bypass graft due to the development of subendothelial hyperplasia.

摘要

在这项研究工作中,通过计算模拟研究了带有吻合术的闭塞动脉的血流动力学场。当前研究的主要目的是研究旁路区域的三维流场现象以及旁路移植物与狭窄体积流量比在其形成过程中的作用。吻合类型为45°角的端侧吻合,而狭窄导致主动脉血管75%的面积阻塞,总容积流量为220升/小时。通过层流模型和三种湍流模型(k-ε RNG、标准k-ω 和 k-ω SST)对流场进行了计算研究。将数值结果与在四种不同流动条件下进行的实验可视化结果进行了定性比较,这些条件根据狭窄与吻合移植物之间的流量比而变化。计算结果与实验可视化结果之间的比较显示出良好的一致性。结果表明,SST k-ω 湍流模型能更好地再现视觉上获得的流动模式。此外,根据流量比,横截面速度分布在旁路移植物下游呈现出两种不同的流动模式。低流量比值的特征是流体卷起,而高流量比值时则观察到流体体积扭曲。最后,绘制了壁面剪应力较低的区域,因为由于内皮增生的发展,这些区域更容易在术后出现旁路移植物退化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/850a/9952429/60f208a9cde7/bioengineering-10-00146-g001.jpg

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