Leipzig B, Oski F A, Cummings C W, Stockman J A, Swender P
J Pediatr. 1979 Feb;94(2):194-6. doi: 10.1016/s0022-3476(79)80821-5.
We evaluated the use of dexamethasone in the management of acute laryngotracheobronchitis (croup). Thirty patients, ranging in age from eight to 60 months, were evaluated in a prospective, double-blind study. Patients received dexamethasone, 0.3 mg/kg at the time of admission and a similar dose 2 hours later, and were compared with a placebo group receiving saline. Sixteen patients received dexamethasone and 14 patients received the placebo. Severity of each group was scored by a standardized system. Patients receiving dexamethasone had a mean admission score of 8.46 points; patients receiving placebo, 8.14. Twenty-four hours after admission the patients in the treatment group had a mean score of 1.19 as contrasted with a score of 5.58 for the placebo group (P less than 0.01). We concluded that dexamethasone when administered in adequate dosage by an intramuscular route hastens the recovery of infants and children with acute uncomplicated croup.
我们评估了地塞米松在急性喉气管支气管炎（哮吼）治疗中的应用。在一项前瞻性双盲研究中，对30名年龄在8至60个月之间的患者进行了评估。患者在入院时接受0.3mg/kg的地塞米松治疗，并在2小时后接受相似剂量的治疗，与接受生理盐水的安慰剂组进行比较。16名患者接受地塞米松治疗，14名患者接受安慰剂治疗。每组的严重程度通过标准化系统进行评分。接受地塞米松治疗的患者入院时平均评分为8.46分；接受安慰剂治疗的患者为8.14分。入院24小时后，治疗组患者的平均评分为1.19分，而安慰剂组为5.58分（P小于0.01）。我们得出结论，通过肌肉注射途径给予足够剂量的地塞米松可加速急性单纯性哮吼婴幼儿的康复。
