Silva Iago Castro da, Conceição Eveson Oscar Almeida, Pereira Daniel Santiago, Rogez Hervé, Muto Nilton Akio
Centre for Valorization of Amazonian Bioactive Compounds & Biological Science Institute, Federal University of Pará, Belém 6075-110, PA, Brazil.
Embrapa Amazônia Oriental, Belém 66095-903, PA, Brazil.
Antibiotics (Basel). 2023 Jan 20;12(2):223. doi: 10.3390/antibiotics12020223.
Many antimicrobial compounds have been seeking to protect the human body against pathogenic microbial infections. In recent times, there has been considerable growth of pathogens resistant to existing drugs due to the inappropriate use of antibiotics. In the present study, bacteria isolated from the honey of stingless bees native to the Amazon called and were used to determine their potential antimicrobial properties and characterize the medium cultivated with isolated bacteria. The results showed inhibition of nine isolates. Among these isolates, SCA12, SCA13, and SCA15 showed inhibitory activity similar to that of vancomycin, which was used as a positive control. The SCA13 strain obtained the best results with antimicrobial extract against the tested pathogens; the species was identified as and its lyophilized extract was characterized by temperature, pH, and trypsin, in which they showed antimicrobial activity. This work shows that bacteria isolated from the stingless bee honey, have the potential to produce antimicrobial substances.
许多抗菌化合物一直致力于保护人体免受病原微生物感染。近年来，由于抗生素的不当使用，对现有药物耐药的病原体数量大幅增长。在本研究中，从亚马逊地区原产的无刺蜂蜂蜜中分离出的名为 和 的细菌，被用于测定它们潜在的抗菌特性，并对用分离出的细菌培养的培养基进行特性分析。结果显示有9种分离株具有抑制作用。在这些分离株中，SCA12、SCA13和SCA15表现出与用作阳性对照的万古霉素相似的抑制活性。SCA13菌株在用抗菌提取物对抗测试病原体时取得了最佳结果；该菌株被鉴定为 ，其冻干提取物通过温度、pH值和胰蛋白酶进行特性分析，结果显示它们具有抗菌活性。这项工作表明，从无刺蜂蜂蜜中分离出的细菌 具有产生抗菌物质的潜力。
