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[内镜下热凝和激光凝固对人体胃壁的体内效应]

[Effect of endoscopic hydrothermo- and laser coagulation on the human stomach wall in vivo].

作者信息

Schwarz C D, Klepetko W, Miholic J, Salem G, Glöckler M, Moeschl P

机构信息

2. Chirurgische Universitätsklinik Wien.

出版信息

Langenbecks Arch Chir. 1987;371(3):201-6. doi: 10.1007/BF01259431.

Abstract

Effect of thermic and laser energy applied onto human in vivo gastric wall has not yet been reported in literature. In our study we evaluated the maximum amount of energy not harming the patient as well as principles for secure and sufficient therapy. In 8 patients hospitalized for gastric resection we applied vaporization by laser- and hydrothermosounds in this part of the stomach which should be resected. Endoscopic pictures were taken. We used a NdYAG laser (maximum performance 70 W, time of application 1-3 s) and hydrothermosounds (maximum performance 170 W, time of application 1-3 s). The stomach was resected 3-8 days following application. Comparing laser- and hydrothermosounds marks we observed a bigger area of necrosis at hydrothermosounds marks using the same amount of energy. In histological investigation correlation between depth and diameter of necrosis was found. After the same application time both depth and diameter of necrosis were bigger by hydrothermosounds than by laser. Lesions reached serosa at the maximum time of application of 3 s. Serosal lesion itself did not appear. Endoscopic treatment of tissue lesion by laser and thermic irradiation (vaporization of bleeding polyp pedicles, treatment of tumors) is secure using the maximum energy mentioned above. Serosal lesion did not appear. Bleeding lesions must be treated by higher energy because of absorption of energy by escaped blood.

摘要

热能量和激光能量作用于人体活体胃壁的效果在文献中尚未见报道。在我们的研究中,我们评估了不伤害患者的最大能量以及安全且充分治疗的原则。在8例因胃切除术住院的患者中,我们对胃的拟切除部分进行了激光汽化和水热超声治疗。拍摄了内镜图像。我们使用了钕钇铝石榴石激光(最大功率70W,作用时间1 - 3秒)和水热超声(最大功率170W,作用时间1 - 3秒)。治疗后3 - 8天切除胃。比较激光和水热超声标记,我们发现在使用相同能量时,水热超声标记处的坏死面积更大。在组织学研究中发现了坏死深度与直径之间的相关性。在相同的作用时间后,水热超声造成的坏死深度和直径均大于激光。在最长作用时间3秒时病变达到浆膜层,但浆膜层本身未出现病变。使用上述最大能量,通过激光和热辐射(汽化出血性息肉蒂、治疗肿瘤)进行内镜下组织病变治疗是安全的,未出现浆膜层病变。由于逸出的血液会吸收能量,出血性病变必须用更高的能量进行治疗。

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