Lnc-uc.147 与肝癌、胃癌和肾癌的疾病分期相关。
Lnc-uc.147 Is Associated with Disease Stage of Liver, Gastric, and Renal Cancer.
机构信息
Laboratory of Human Cytogenetics and Oncogenetics, Department of Genetics, Universidade Federal do Paraná, Curitiba 19031, PR, Brazil.
Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, State University of Campinas, Limeira 13484-350, SP, Brazil.
出版信息
Biomolecules. 2023 Jan 31;13(2):265. doi: 10.3390/biom13020265.
Lnc-uc.147, a long non-coding RNA derived from a transcribed ultraconserved region (T-UCR), was previously evidenced in breast cancer. However, the role of this region in other tumor types was not previously investigated. The present study aimed to investigate lnc-uc.147 in different types of cancer, as well as to suggest lnc-uc.147 functional and regulation aspects. From solid tumor datasets analysis of The Cancer Genome Atlas (TCGA), deregulated lnc-uc.147 expression was associated with the histologic grade of hepatocellular carcinoma, and with the tumor stage of clear cell renal and gastric adenocarcinoma. Considering the epidemiologic relevance of liver cancer, silencing lnc-uc.147 reduced the viability and clonogenic capacity of HepG2 cell lines. Additionally, we suggest a relation between the transcription factor TEAD4 and lnc-uc.147 in liver and breast cancer cells.
Lnc-uc.147 是一种长链非编码 RNA，来源于转录的超保守区域（T-UCR），先前在乳腺癌中得到证实。然而，该区域在其他肿瘤类型中的作用尚未被研究过。本研究旨在研究 lnc-uc.147 在不同类型的癌症中的作用，并提出 lnc-uc.147 的功能和调节方面的问题。从癌症基因组图谱（TCGA）的实体瘤数据集分析中，lnc-uc.147 的表达失调与肝细胞癌的组织学分级以及透明细胞肾和胃腺癌的肿瘤分期有关。考虑到肝癌的流行病学相关性，沉默 lnc-uc.147 降低了 HepG2 细胞系的活力和克隆形成能力。此外，我们还提出了转录因子 TEAD4 与肝癌和乳腺癌细胞中 lnc-uc.147 之间的关系。
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