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基因表达调控检测的因素和方法。

Factors and Methods for the Detection of Gene Expression Regulation.

机构信息

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

出版信息

Biomolecules. 2023 Feb 6;13(2):304. doi: 10.3390/biom13020304.

DOI:10.3390/biom13020304
PMID:36830673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9953580/
Abstract

Gene-expression regulation involves multiple processes and a range of regulatory factors. In this review, we describe the key factors that regulate gene expression, including transcription factors (TFs), chromatin accessibility, histone modifications, DNA methylation, and RNA modifications. In addition, we also describe methods that can be used to detect these regulatory factors.

摘要

基因表达调控涉及多个过程和一系列调节因子。在这篇综述中，我们描述了调节基因表达的关键因素，包括转录因子（TFs）、染色质可及性、组蛋白修饰、DNA 甲基化和 RNA 修饰。此外，我们还描述了可用于检测这些调节因子的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/f9228745b5e7/biomolecules-13-00304-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/a9622affeb6f/biomolecules-13-00304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/1db0a4f4a5c0/biomolecules-13-00304-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/1af9e3bc3940/biomolecules-13-00304-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/eede1ebb4432/biomolecules-13-00304-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/9098efc5dd06/biomolecules-13-00304-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/f9228745b5e7/biomolecules-13-00304-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/a9622affeb6f/biomolecules-13-00304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/1db0a4f4a5c0/biomolecules-13-00304-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/1af9e3bc3940/biomolecules-13-00304-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/eede1ebb4432/biomolecules-13-00304-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/9098efc5dd06/biomolecules-13-00304-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22e7/9953580/f9228745b5e7/biomolecules-13-00304-g006.jpg

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Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells.
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Sci Immunol. 2022 Aug 5;7(74):eabj9123. doi: 10.1126/sciimmunol.abj9123.
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