可卡因抑制家兔鼻和口腔组织中外源性去甲肾上腺素的神经元外O-甲基化。
Cocaine inhibits extraneuronal O-methylation of exogenous norepinephrine in nasal and oral tissues of the rabbit.
作者信息
de la Lande I S, Parker D A, Proctor C H, Marino V, Mackay-Sim A
机构信息
Department of Clinical and Experimental Pharmacology, University of Adelaide, South Australia.
出版信息
Life Sci. 1987 Nov 30;41(22):2463-8. doi: 10.1016/0024-3205(87)90672-2.
Nasal mucosa (respiratory and olfactory) and lingual gingiva of the rabbit were depleted of their sympathetic nerves by superior cervical ganglionectomy. In the innervated nasal mucosa, exogenous tritiated norepinephrine (3H-NE) was metabolised mainly to tritiated 3,4-dihydroxyphenylethylene glycol (3HDOPEG) and 3,4-dihydroxy mandelic acid (3HDOMA), whereas after denervation it was metabolised mainly to tritiated normetanephrine (3HNMN). In the denervated mucosa, cocaine (30 umol/1) inhibited 3HNMN formation by 50-60%. Cocaine also inhibited 3HNMN formation by 60% in the denervated lingual gingiva. It is concluded that the tissues metabolise 3H-NE via a cocaine-sensitive extraneuronal uptake and O-methylating system similar to that which has been shown to be present in dental pulp.
通过切除兔颈上神经节，去除其鼻腔黏膜（呼吸性和嗅觉性）及舌龈的交感神经。在有神经支配的鼻腔黏膜中，外源性氚标记去甲肾上腺素（3H-NE）主要代谢为氚标记的3,4-二羟基苯乙二醇（3HDOPEG）和3,4-二羟基扁桃酸（3HDOMA），而在去神经支配后，它主要代谢为氚标记的去甲变肾上腺素（3HNMN）。在去神经支配的黏膜中，可卡因（30 μmol/L）抑制3HNMN的形成达50%-60%。可卡因在去神经支配的舌龈中也抑制60%的3HNMN形成。结论是，这些组织通过一种对可卡因敏感的非神经摄取和O-甲基化系统代谢3H-NE，该系统类似于已证实在牙髓中存在的系统。
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