DiogenX, 180 Avenue du Prado, 13008 Marseille, France.
Université Côte d'Azur, CNRS, Inserm, iBV, 06000 Nice, France.
Cells. 2023 Feb 9;12(4):565. doi: 10.3390/cells12040565.
The pancreas is an abdominal gland that serves 2 vital purposes: assist food processing by secreting digestive enzymes and regulate blood glucose levels by releasing endocrine hormones. During embryonic development, this gland originates from epithelial buds located on opposite sites of the foregut endoderm. Pancreatic cell specification and maturation are coordinated by a complex interplay of extrinsic and intrinsic signaling events. In the recent years, the canonical Wnt/β-catenin pathway has emerged as an important player of pancreas organogenesis, regulating pancreatic epithelium specification, compartmentalization and expansion. Importantly, it has been suggested to regulate proliferation, survival and function of adult pancreatic cells, including insulin-secreting β-cells. This review summarizes recent work on the role of Wnt/β-catenin signaling in pancreas biology from early development to adulthood, emphasizing on its relevance for the development of new therapies for pancreatic diseases.
胰腺是一种腹部腺体，具有两个重要功能：通过分泌消化酶辅助食物加工，通过释放内分泌激素调节血糖水平。在胚胎发育过程中，该腺体起源于前肠内胚层相对位置的上皮芽。胰腺细胞的特化和成熟是由外在和内在信号事件的复杂相互作用协调的。近年来，经典的 Wnt/β-连环蛋白途径已成为胰腺器官发生的重要参与者，调节胰腺上皮的特化、区室化和扩张。重要的是，它被认为调节成年胰腺细胞，包括胰岛素分泌β细胞的增殖、存活和功能。这篇综述总结了 Wnt/β-连环蛋白信号在从早期发育到成年期的胰腺生物学中的作用的最新研究，强调了其在开发胰腺疾病新疗法方面的相关性。
