Adeerjiang Yilinuer, Sidike Abudulimu, Gan Xiao-Xue, Li Qin-Tian, Jiang Sheng
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, China,
Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China,
Cardiorenal Med. 2025;15(1):72-82. doi: 10.1159/000543145. Epub 2024 Dec 20.
Diabetes mellitus is a prevalent chronic disease that is becoming increasingly common worldwide and can lead to a number of dangerous complications. The Wnt signaling pathway is important for the onset and progression of diabetes. Wnt3a is a typical Wnt ligand that can increase the stability of β-catenin, control TCF7L2 expression, promote β-cell proliferation, and reduce apoptosis.
The involvement of the Wnt3a/β-catenin/TCF7L2 signaling pathway in the development of diabetes and associated problems related to the kidneys is reviewed in this article.
We believe that a thorough comprehension of the molecular connections between diabetes and signaling pathways will eventually lead to improved diabetes management.
糖尿病是一种常见的慢性疾病，在全球范围内日益普遍，并可导致多种危险并发症。Wnt信号通路对糖尿病的发生和发展至关重要。Wnt3a是一种典型的Wnt配体，可增加β-连环蛋白的稳定性，控制TCF7L2表达，促进β细胞增殖并减少细胞凋亡。
本文综述了Wnt3a/β-连环蛋白/TCF7L2信号通路在糖尿病发展及肾脏相关问题中的作用。
我们认为，深入理解糖尿病与信号通路之间的分子联系最终将改善糖尿病的管理。
