不同间歇性禁食方案对大鼠高血糖诱导的认知功能障碍的影响
Effect of Various Intermittent Fasting Protocols on Hyperglycemia-Induced Cognitive Dysfunction in Rats.
作者信息
Alfheeaid Hani A, Alhowail Ahmad A, Ahmed Faiyaz, Zaki Abdel Kader A, Alkhaldy Areej
机构信息
Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah 51452, Saudi Arabia.
Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.
出版信息
Brain Sci. 2023 Jan 18;13(2):165. doi: 10.3390/brainsci13020165.
Diabetes mellitus is a highly prevalent metabolic disorder that causes cognitive decline. Here, we investigated the impact of various intermittent fasting protocols on type 2 diabetes mellitus (T2DM)-induced cognitive dysfunction in a rodent model. Male Sprague-Dawley rats (aged 3 months) were randomly assigned to five groups (n = 6 per group) and T2DM was induced by streptozotocin (60 mg/kg, IM). The control group was untreated. Cognitive function was tested (Y-maze, novel object recognition, and elevated plus maze tests) and glucose was assessed. The T2DM rats exhibited significantly higher blood glucose, which is associated with cognitive dysfunction. Compared to the validated animal model of T2DM in rats, various intermittent fasting protocols decreased blood glucose and improved cognitive function. These results indicate that various intermittent fasting protocols may be a potential strategy for managing the hyperglycemia-associated cognitive dysfunction.
糖尿病是一种高度流行的代谢紊乱疾病，可导致认知能力下降。在此，我们在啮齿动物模型中研究了各种间歇性禁食方案对2型糖尿病（T2DM）诱导的认知功能障碍的影响。将雄性Sprague-Dawley大鼠（3个月龄）随机分为五组（每组n = 6），并用链脲佐菌素（60 mg/kg，腹腔注射）诱导T2DM。对照组未接受治疗。测试认知功能（Y迷宫、新物体识别和高架十字迷宫测试）并评估血糖。T2DM大鼠的血糖显著更高，这与认知功能障碍有关。与已验证的大鼠T2DM动物模型相比，各种间歇性禁食方案可降低血糖并改善认知功能。这些结果表明，各种间歇性禁食方案可能是管理与高血糖相关的认知功能障碍的潜在策略。
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