Ebada Mahmoud A, Mostafa Abdalrhman, Gadallah Al-Hussein A, Alkanj Souad, Alghamdi Badrah S, Ashraf Ghulam Md, Abuzenadah Adel M, Alserihi Raed F, Wadaa-Allah Ahmed, Salama Mohamed
Neurologist, Nasr City Hospital for Health Insurance, Cairo 11765, Egypt.
Resident, Egyptian Fellowship of Neurology, Ministry of Health and Population of Egypt, Cairo 4262124, Egypt.
Brain Sci. 2023 Jan 31;13(2):243. doi: 10.3390/brainsci13020243.
Finding a link between a hormone and microRNAs (miRNAs) is of great importance since it enables the adjustment of genetic composition or cellular functions without needing gene-level interventions. The dicer-mediated cleavage of precursor miRNAs is an interface link between miRNA and its regulators; any disruption in this process can affect neurogenesis. Besides, the hormonal regulation of miRNAs can occur at the molecular and cellular levels, both directly, through binding to the promoter elements of miRNAs, and indirectly, via regulation of the signaling effects of the post-transcriptional processing proteins. Estrogenic hormones have many roles in regulating miRNAs in the brain. This review discusses miRNAs, their detailed biogenesis, activities, and both the general and estrogen-dependent regulations. Additionally, we highlight the relationship between miR-29, miR-9, and estrogens in the nervous system. Such a relationship could be a possible etiological route for developing various neurodegenerative disorders.
发现激素与微小RNA（miRNA）之间的联系非常重要，因为这能够在无需基因水平干预的情况下调节基因组成或细胞功能。Dicer介导的前体miRNA切割是miRNA与其调节因子之间的一个界面联系；该过程中的任何干扰都可能影响神经发生。此外，miRNA的激素调节可在分子和细胞水平上发生，既可以直接通过与miRNA的启动子元件结合，也可以间接通过调节转录后加工蛋白的信号作用来实现。雌激素在调节大脑中的miRNA方面具有多种作用。本综述讨论了miRNA、其详细的生物发生、活性以及一般和雌激素依赖性调节。此外，我们强调了神经系统中miR-29、miR-9与雌激素之间的关系。这种关系可能是发展各种神经退行性疾病的一个可能的病因途径。
