Shaanxi Key Laboratory of Chemical Additives for Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
School of Chemistry and Chemical Engineering, School of Environment, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210023, China.
Biosensors (Basel). 2023 Jan 22;13(2):175. doi: 10.3390/bios13020175.
Electrochemical biosensors, in which enzymatic biofuel cells simultaneously work as energy power and signal generators, have become a research hotspot. They display the merits of power self-support, a simplified structure, in vivo operational feasibility, online and timely monitoring, etc. Since the concept of enzymatic biofuel cell-powered biosensors (EBFC-SPBs) was first proposed, its applications in health monitoring have scored tremendous achievements. However, the creation and practical application of portable EBFC-SPBs are still impeded by the difficulty in their miniaturization. In recent years, the booming microfluidic technology has powerfully pushed forward the progress made in miniaturized and portable EBFC-SPBs. This brief review recalls and summarizes the achievements and progress made in miniaturized EBFC-SPBs. In addition, we also discuss the advantages and challenges that microfluidic and screen-printing technologies provide to wearable and disposable EBFC-SPBs.
电化学生物传感器中，酶生物燃料电池同时作为能量电源和信号发生器，已成为研究热点。它们具有自支撑电源、结构简化、体内操作可行性、在线实时监测等优点。自从酶生物燃料电池供电的生物传感器（EBFC-SPBs）的概念首次提出以来，它在健康监测中的应用已经取得了巨大的成就。然而，便携式 EBFC-SPBs 的创造和实际应用仍然受到其小型化的困难的阻碍。近年来，蓬勃发展的微流控技术有力地推动了小型化和便携式 EBFC-SPBs 的进展。本文简要回顾和总结了小型化 EBFC-SPBs 的成就和进展。此外，我们还讨论了微流控和丝网印刷技术为可穿戴和一次性 EBFC-SPBs 提供的优势和挑战。
