Kovacevic Lucija, Petrovecki Marko, Korsa Lea, Marusic Zlatko, Dumic-Cule Ivo, Prutki Maja
Clinical Department of Diagnostic and Interventional Radiology, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
Clinical Department of Pathology and Cytology, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
Diagnostics (Basel). 2023 Feb 12;13(4):694. doi: 10.3390/diagnostics13040694.
This study aimed to evaluate the performance of multiparametric breast magnetic resonance imaging (mpMRI) for predicting response to neoadjuvant chemotherapy (NAC) in patients with luminal B subtype breast cancer. The prospective study included thirty-five patients treated with NAC for both early and locally advanced breast cancer of the luminal B subtype at the University Hospital Centre Zagreb between January 2015 and December 2018. All patients underwent breast mpMRI before and after two cycles of NAC. Evaluation of mpMRI examinations included analysis of both morphological (shape, margins, and pattern of enhancement) and kinetic characteristics (initial signal increase and post-initial behavior of the time-signal intensity curve), which were additionally interpreted with a Göttingen score (GS). Histopathological analysis of surgical specimens included grading the tumor response based on the residual cancer burden (RCB) grading system and revealed 29 NAC responders (RCB-0 (pCR), I, II) and 6 NAC non-responders (RCB-III). Changes in GS were compared with RCB classes. A lack of GS decrease after the second cycle of NAC is associated with RCB class and non-responders to NAC.
本研究旨在评估多参数乳腺磁共振成像（mpMRI）对管腔B亚型乳腺癌患者新辅助化疗（NAC）反应的预测性能。这项前瞻性研究纳入了2015年1月至2018年12月期间在萨格勒布大学医院中心接受NAC治疗的35例管腔B亚型早期和局部晚期乳腺癌患者。所有患者在NAC两个周期前后均接受了乳腺mpMRI检查。mpMRI检查的评估包括形态学（形状、边缘和强化模式）和动力学特征（初始信号增加和时间-信号强度曲线的初始后行为）分析，并额外采用哥廷根评分（GS）进行解读。手术标本的组织病理学分析包括根据残余癌负担（RCB）分级系统对肿瘤反应进行分级，结果显示29例NAC反应者（RCB-0（pCR）、I、II）和6例NAC无反应者（RCB-III）。将GS的变化与RCB类别进行比较。NAC第二个周期后GS缺乏下降与RCB类别和NAC无反应者相关。
