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一例原发性肾脏软组织巨细胞瘤导致腹膜播散，考虑为恶性转化：病例报告

A Primary Kidney Giant Cell Tumor of Soft Tissue Caused Peritoneal Dissemination, Considered to Be Malignant Transformation: A Case Report.

作者信息

Hata Chiina, Fukawa Yuki, Motoi Toru, Kinowaki Yuko, Akashi Takumi, Ohashi Kenichi, Ishikawa Yudai, Waseda Yuma, Fujii Yasuhisa, Kakuta Ryota, Ikeda Sadakatsu, Onishi Iichiroh

机构信息

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

出版信息

Diagnostics (Basel). 2023 Feb 16;13(4):752. doi: 10.3390/diagnostics13040752.

DOI:10.3390/diagnostics13040752
PMID:36832239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9955081/
Abstract

Giant cell tumor of soft tissue (GCTST) is a defined disease entity that has a morphology similar to giant cell tumor of bone (GCTB). The malignant transformation of GCTST has not been reported, and a kidney primary is extremely rare. We report the case of a 77-year-old Japanese male, who was diagnosed with primary GCTST of the kidney and showed peritoneal dissemination, considered to be a malignant transformation of GCTST, in 4 years and 5 months. Histologically, the primary lesion showed characteristics of round cells with not prominent atypia, multi-nucleated giant cells, and osteoid formation, and carcinoma components were not found. The peritoneal lesion was characterized by osteoid formation and round to spindle-shaped cells, but differed in nuclear atypia, and multi-nucleated giant cells were not detected. Immunohistochemical and cancer genome sequence analysis suggested these tumors were sequential. This is a first report of a case that we could diagnose as primary GCTST of the kidney and could be determined as malignant transformation of GCTST in the clinical course. Analysis of this case will be examined in the future when genetic mutations and the disease concepts of GCTST are established.

摘要

软组织巨细胞瘤（GCTST）是一种明确的疾病实体，其形态与骨巨细胞瘤（GCTB）相似。GCTST的恶性转化尚未见报道，肾脏原发性GCTST极为罕见。我们报告一例77岁日本男性病例，其被诊断为肾脏原发性GCTST，并在4年5个月时出现腹膜播散，考虑为GCTST的恶性转化。组织学上，原发灶表现为圆形细胞特征，无异型性显著，有多核巨细胞和类骨质形成，未发现癌成分。腹膜病灶以类骨质形成和圆形至梭形细胞为特征，但核异型性不同，未检测到多核巨细胞。免疫组化和癌症基因组序列分析提示这些肿瘤具有连续性。这是首例我们能够诊断为肾脏原发性GCTST且在临床过程中可确定为GCTST恶性转化的病例报告。当GCTST的基因突变和疾病概念确立后，未来将对该病例进行分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1417/9955081/2605e8ab644d/diagnostics-13-00752-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1417/9955081/5b5f2d3bf272/diagnostics-13-00752-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1417/9955081/acb313e58c01/diagnostics-13-00752-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1417/9955081/3dab8e23d4b7/diagnostics-13-00752-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1417/9955081/1c7499a332aa/diagnostics-13-00752-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1417/9955081/2605e8ab644d/diagnostics-13-00752-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1417/9955081/5b5f2d3bf272/diagnostics-13-00752-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1417/9955081/acb313e58c01/diagnostics-13-00752-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1417/9955081/3dab8e23d4b7/diagnostics-13-00752-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1417/9955081/1c7499a332aa/diagnostics-13-00752-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1417/9955081/2605e8ab644d/diagnostics-13-00752-g005.jpg

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本文引用的文献

1
Primer malignant giant cell tumour of kidney: a case report.肾脏原发性恶性巨细胞瘤 1 例报告。
Ann R Coll Surg Engl. 2021 Oct;103(9):e288-e291. doi: 10.1308/rcsann.2020.7113. Epub 2021 Apr 14.
2
Absence of H3F3A mutation in a subset of malignant giant cell tumor of bone.在恶性骨巨细胞瘤的一个亚组中不存在 H3F3A 突变。
Mod Pathol. 2019 Dec;32(12):1751-1761. doi: 10.1038/s41379-019-0318-5. Epub 2019 Jul 8.
3
A case report of primary osteosarcoma originating from kidney.一例源自肾脏的原发性骨肉瘤病例报告。
Medicine (Baltimore). 2019 Jan;98(4):e14234. doi: 10.1097/MD.0000000000014234.
4
An expanded immunohistochemical profile of osteoclast-rich undifferentiated carcinoma of the urinary tract.富含破骨细胞的未分化尿路移行细胞癌的免疫组织化学特征分析。
Mod Pathol. 2018 Jun;31(6):984-988. doi: 10.1038/s41379-018-0012-z. Epub 2018 Feb 6.
5
Clear cell renal cell carcinoma with a syncytial-type multinucleated giant tumor cell component: implications for differential diagnosis.透明细胞肾细胞癌伴合胞体样多形性巨细胞肿瘤成分：对鉴别诊断的意义。
Hum Pathol. 2014 Apr;45(4):735-44. doi: 10.1016/j.humpath.2013.10.033. Epub 2013 Nov 15.
6
Solitary osteoclast-like giant cell tumor of the kidney: a case report.肾脏孤立性破骨细胞样巨细胞瘤：病例报告。
Urology. 2012 Nov;80(5):e67-8. doi: 10.1016/j.urology.2012.06.047.
7
Osteoclast-rich undifferentiated carcinoma of the urinary bladder: an immunohistochemical study.富含破骨细胞的未分化膀胱癌：一项免疫组织化学研究。
Pathol Res Pract. 2011 Nov 15;207(11):722-7. doi: 10.1016/j.prp.2011.09.003. Epub 2011 Oct 22.
8
Role of adjuvant radiation therapy in unusually rare primary malignant osteoclast-like giant cell tumor of the kidney.辅助放疗在极其罕见的原发性肾恶性破骨细胞样巨细胞瘤中的作用。
Indian J Cancer. 2011 Jan-Mar;48(1):123-4. doi: 10.4103/0019-509X.76638.
9
Undifferentiated carcinoma of the renal pelvis with osteoclast-like giant cells: a report of two cases.肾盂未分化癌伴破骨细胞样巨细胞：两例报告。
APMIS. 2010 May;118(5):407-12. doi: 10.1111/j.1600-0463.2010.02608.x.
10
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Diagn Pathol. 2009 Dec 31;4:48. doi: 10.1186/1746-1596-4-48.