Department of Pathology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan.
Pathol Res Pract. 2011 Nov 15;207(11):722-7. doi: 10.1016/j.prp.2011.09.003. Epub 2011 Oct 22.
Osteoclast-rich undifferentiated carcinoma of the urinary tract is a rare tumor which histologically mimicks giant cell tumor of bone. The histogenesis of this tumor has not been clarified yet although its urothelial origin is proposed on the basis of positive reactions of an epithelial marker on mononuclear undifferentiated tumor cells and the existence of foci of a urothelial carcinoma component in some cases. We experienced a case of urinary bladder tumor diagnosed as osteoclastic-rich undifferentiated carcinoma, and performed an immunohistochemical study on the expression of various markers, including stem cell markers to further characterize the tumor properties. Immunohistochemically, CD56, nestin, and Sox2 were expressed in diffusely proliferating mononuclear tumor cells of undifferentiated features, suggesting the stemness properties of these cells. These findings might provide the clue as to the clarification of the pathogenesis of this rare tumor.
富含破骨细胞的未分化尿路癌是一种罕见的肿瘤，其组织学上类似于骨巨细胞瘤。尽管该肿瘤的发生机制尚未阐明，但基于单核未分化肿瘤细胞上皮标志物的阳性反应和某些情况下存在尿路上皮癌成分的灶性存在，提出了其尿路上皮起源。我们遇到了一例被诊断为富含破骨细胞的未分化膀胱癌，并对各种标志物的表达进行了免疫组织化学研究，包括干细胞标志物，以进一步表征肿瘤特性。免疫组织化学结果显示，弥漫性增殖的未分化特征的单核肿瘤细胞中表达 CD56、巢蛋白和 Sox2，提示这些细胞具有干细胞特性。这些发现可能为阐明这种罕见肿瘤的发病机制提供线索。
