Sitki Kocman University, Mugla, Turkey.
Ann R Coll Surg Engl. 2021 Oct;103(9):e288-e291. doi: 10.1308/rcsann.2020.7113. Epub 2021 Apr 14.
Osteoclast-like giant cell tumours of the kidney are extremely rare and usually accompanied by a conventional urothelial neoplasm such as papillary, transitional renal cell, or sarcomatoid carcinoma. Although they have morphological features similar to those of the giant cell tumours in the skeletal system, their counterparts in the urinary system show highly malignant features. Our case is the third primer malignant giant cell tumour of the kidney in the literature. The patient was a 50-year-old male and underwent nephroureterectomy for a mass of 18×14×13cm in his left kidney. However, the patient died in the second month postoperatively as a result of local recurrences and multiple distant metastases. The general condition of the patient deteriorated progressively; hence, he could not have any adjuvant therapy. Having more information about the pathological and clinical findings of these exceedingly rare tumours can help inform treatment steps.
肾脏破骨细胞样巨细胞瘤极为罕见，通常伴有传统的尿路上皮肿瘤，如乳头状、移行细胞或肉瘤样癌。尽管它们具有与骨骼系统中的巨细胞瘤相似的形态特征，但泌尿系统中的对应物表现出高度恶性的特征。我们的病例是文献中第三例原发性肾脏恶性巨细胞瘤。患者为 50 岁男性，因左肾 18×14×13cm 肿块行肾输尿管切除术。然而，患者术后第二个月因局部复发和多处远处转移而死亡。患者的一般状况逐渐恶化；因此，他无法接受任何辅助治疗。了解这些极为罕见的肿瘤的更多病理和临床发现可以帮助指导治疗步骤。
