Hu Jiamiao, Lin Zhongjing, Li Lanxin, Zheng Baodong, Zeng Hongliang, Wang Yanbo, Zhang Yi
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fuzhou 350002, China.
Foods. 2023 Feb 8;12(4):737. doi: 10.3390/foods12040737.
Food allergy is a serious food safety and public health issue. However, the medical interventions for allergy treatment are still suboptimal. Recently, the gut microbiome-immune axis has been considered as a promising target to reduce the symptoms of food allergy. In this study, we explore the oral administration of lotus-seed resistant starch as a means to protect against food allergy using an ovalbumin (OVA) sensitization and challenge rodent model. The results obtained showed that lotus-seed resistant starch intervention alleviated the food allergy symptoms (such as reductions in body temperature and allergic diarrhea). Furthermore, lotus-seed resistant starch also attenuated the increase in OVA-specific immunoglobulins and improved Th1/Th2 imbalance in OVA-sensitized mice. These anti-allergic effects might be associated with the actions of lotus-seed resistant starch on intestinal microbiota. Taken together, our findings suggest that daily ingestion of lotus-seed resistant starch might be effective for the alleviation of food allergy.
食物过敏是一个严重的食品安全和公共卫生问题。然而，用于过敏治疗的医学干预措施仍不尽人意。最近，肠道微生物群-免疫轴被认为是减轻食物过敏症状的一个有前景的靶点。在本研究中，我们利用卵清蛋白（OVA）致敏和激发啮齿动物模型，探索口服莲子抗性淀粉作为预防食物过敏的一种手段。获得的结果表明，莲子抗性淀粉干预减轻了食物过敏症状（如体温降低和过敏性腹泻）。此外，莲子抗性淀粉还减弱了OVA特异性免疫球蛋白的增加，并改善了OVA致敏小鼠的Th1/Th2失衡。这些抗过敏作用可能与莲子抗性淀粉对肠道微生物群的作用有关。综上所述，我们的研究结果表明，每日摄入莲子抗性淀粉可能对减轻食物过敏有效。
