Department of Orthopedic Surgery, 1st Affiliated Hospital of Soochow University, Suzhou 215005, China.
Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
Genes (Basel). 2023 Feb 4;14(2):408. doi: 10.3390/genes14020408.
Temporomandibular joint disorders (TMDs) are conditions that affect the muscles of mastication and joints that connect the mandible to the base of the skull. Although TMJ disorders are associated with symptoms, the causes are not well proven. Chemokines play an important role in the pathogenesis of TMJ disease by promoting chemotaxis inflammatory cells to destroy the joint synovium, cartilage, subchondral bone, and other structures. Therefore, enhancing our understanding of chemokines is critical for developing appropriate treatment of TMJ. In this review, we discuss chemokines including MCP-1, MIP-1α, MIP-3a, RANTES, IL-8, SDF-1, and fractalkine that are known to be involved in TMJ diseases. In addition, we present novel findings that CCL2 is involved in β-catenin-mediated TMJ osteoarthritis (OA) and potential molecular targets for the development of effective therapies. The effects of common inflammatory factors, IL-1β and TNF-α, on chemotaxis are also described. In conclusion, this review aims to provide a theoretical basis for future chemokine-targeted therapies for TMJ OA.
颞下颌关节紊乱病（TMDs）是影响咀嚼肌和下颌骨与颅底连接关节的疾病。虽然 TMJ 疾病与症状有关，但病因尚未得到充分证实。趋化因子通过促进炎症细胞趋化来破坏关节滑膜、软骨、软骨下骨和其他结构，在 TMJ 疾病的发病机制中发挥重要作用。因此，加深我们对趋化因子的理解对于开发 TMJ 的适当治疗方法至关重要。在这篇综述中，我们讨论了已知参与 TMJ 疾病的趋化因子，包括 MCP-1、MIP-1α、MIP-3a、RANTES、IL-8、SDF-1 和 fractalkine。此外，我们还介绍了 CCL2 参与β-连环蛋白介导的 TMJ 骨关节炎（OA）的新发现以及开发有效治疗方法的潜在分子靶点。还描述了常见炎症因子 IL-1β 和 TNF-α 对趋化作用的影响。总之，本综述旨在为未来 TMJ OA 的趋化因子靶向治疗提供理论基础。
